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FeNC nanozyme-based electrochemical immunoassay for sensitive detection of human epidermal growth factor receptor 2
The proof-of-concept of sensitive electrochemical immunoassay for the quantitative monitoring of human epidermal growth factor receptor 2 (HER2) is...
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A “signal-on” photoelectrochemical sensor for human epidermal growth factor receptor 2 detection based on Y6/CdS organic–inorganic heterojunction
A “signal-on” photoelectrochemical (PEC) immunosensor was successfully constructed for determination of human epidermal growth factor receptor 2...
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Efficient expression of fusion human epidermal growth factor in tobacco chloroplasts
BackgroundChloroplast transformation is a robust technology for the expression of recombinant proteins. Various types of pharmaceutical proteins...
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Electrochemical Biosensors for Soluble Epidermal Growth Factor Receptor Detection
Simple detection of oncomarkers is of paramount importance in cancer diagnosis. Screen-printed carbon electrodes (SPCEs) were modified by...
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New Biginelli derivatives with trifluoro extension as inhibitors of epidermal growth factor receptor tyrosine kinase: molecular docking study in comparison with monastrol
New tetrahydropyrimidone derivatives with structural modifications of anti-cancer drug, monastrol, were synthesized, and molecular docking study of...
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Mechanistic investigation into selective cytotoxic activities of gold nanoparticles functionalized with epidermal growth factor variants
Epidermal growth factor (EGF) gains unique selective cytotoxicity against cancer cells upon conjugation with gold nanoparticles (GNPs). We have...
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Hyaluronic acid-based biodegradable microneedles loaded with epidermal growth factor for treatment of diabetic foot
Pain relief and effective methods of treating patients with diabetic foot wounds have yet to be established. Improved surgical treatment, other than...
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Equilibrium Between Dimeric and Monomeric Forms of Human Epidermal Growth Factor is Shifted Towards Dimers in a Solution
An interplay between monomeric and dimeric forms of human epidermal growth factor (EGF) affecting its interaction with EGF receptor (EGFR) is poorly...
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Photoelectrochemical detection of human epidermal growth factor receptor 2 (HER2) based on Co3O4-ascorbic acid oxidase as multiple signal amplifier
A sensitive photoelectrochemical (PEC) sensor based on hexagonal carbon nitride tubes (HCNT) as photoactive material was prepared for the detection...
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Effect of Epidermal Growth Factor on the Colony-formation Ability of Porcine Spermatogonial Germ Cells
Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis, studying germ line stem cell biology, and producing transgenic animals....
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Paper Title “Hu7CG2: A Novel Humanized Anti-Epidermal Growth Factor Receptor (EGFR) Biparatopic Nanobody”
Targeted therapy is an effective and appropriate approach with low side effects in cancer therapy compared with other treatment approaches. Epidermal...
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Basic Amino Acids Within the Juxtamembrane Domain of the Epidermal Growth Factor Receptor Regulate Receptor Dimerization and Auto-phosphorylation
Epidermal growth factor receptor (EGFR) dysregulation is observed in many human cancers and is both a cause of oncogenesis and a target for...
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Rational Design and Production of Bioactive Analogs of Recombinant Human Keratinocyte Growth Factor (rhKGF) with Reduced Aggregation Propensity
Recombinant human keratinocyte growth factor (rhKGF) is a highly aggregation-prone therapeutic protein. The present study aimed to reduce aggregation...
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Dual-label time-resolved fluoroimmunoassay for simultaneous measurement of human epidermal growth factor receptor 2 and human epididymis protein 4 in serum
In this study, a novel dual-label time-resolved fluoroimmunoassay (TRFIA) is described for simultaneous quantification of human epidermal growth...
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In vitro anti-cancer effects of gefitinib via EGF receptor-targeted delivery on triple-negative breast cancer cells
Targeting the epidermal growth factor receptor (EGFR) is an alternative therapeutic strategy for the treatment of triple-negative breast cancer...
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Epidermal Growth Factor-gold Nanoparticle Conjugates-induced Cellular Responses: Effect of Interfacial Parameters between Cell and Nanoparticle
The original activity of epidermal growth factor (EGF) is to promote cell growth or block their apoptosis. However, its activity changes to...
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Dual antibody-aided mesoporous nanoreactor for H2O2 self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) represents a formidable challenge due to the absence of estrogen receptor (ER), progesterone receptor (PR), and...
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A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
AbstractA new human uveal melanoma (UM) cell line uMel1 was established by mechanical disintegration of a tumor fragment. uMel1 cells had a stellate...
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Targeting growth of breast cancer cell line (MCF-7) with curcumin-pyrimidine analogs
A series of curcumin-pyrimidine analogs ( 3a - 3h ) were synthesized with good yields using phase transfer catalysis. The antiproliferative activities of...
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Refolding, Crystallization, and Crystal Structure Analysis of a Scavenger Receptor Cysteine-Rich Domain of Human Salivary Agglutinin Expressed in Escherichia coli
Scavenger receptors are a protein superfamily that typically consists of one or more repeats of the scavenger receptor cysteine-rich structural...