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The Hippocampus in Anorexia Nervosa
The hippocampus is an anatomically complex structure that is peculiarly involved in the neurobiology of different brain disorders. At present,...
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The Hippocampus in Anorexia Nervosa
The hippocampus is an anatomically complex structure that is peculiarly involved in the neurobiology of different brain disorders. At present,...
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Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling
More Americans are consuming diets higher in saturated fats and refined sugars than ever before. These trends could have serious consequences for the...
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Hippocampus and its involvement in Alzheimer’s disease: a review
Hippocampus is the significant component of the limbic lobe, which is further subdivided into the dentate gyrus and parts of Cornu Ammonis. It is the...
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Tarooneh extract relieves anxiety-like behaviors and cognitive deficits by inhibiting synaptic loss in the hippocampus and frontal cortex in rats subjected to chronic restraint stress
In traditional medicine, Tarooneh (a hardcover of the date palm; Phoenix dactylifera) has known as a sedative and relaxant medicine. In this study,...
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Proteomic profiling of the rat hippocampus from the kindling models of electrical epilepsy and treatment with low-frequency deep brain stimulation: the important role of the cytoskeleton
Epilepsy is one of the most common neurological diseases and affects 1–2% of the world’s population. Epilepsy is associated with recurrent and...
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Purified Native Protein Extracted from the Venom of Agelena orientalis Attenuates Memory Defects in the Rat Model of Glutamate-Induced Excitotoxicity
Spider venom contains various peptides and proteins, which can be used for pharmacological applications. Finding novel therapeutic strategies against...
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Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats
High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions...
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Hyperoside ameliorates depression-like behavior in ovariectomized mice
The physiological changes caused by the decline in estrogen levels due to menopause are linked to an increased risk of depression. This study...
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A high fat diet potentiates neonatal iron overload-induced memory impairments in rats
PurposeThe present study aimed at evaluating possible synergistic effects between two risk factors for cognitive decline and neurodegenerative...
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Chrysophanol improves memory ability of d-galactose and Aβ25–35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM–CaMKIV signal pathway in hippocampus
This study was aimed to investigate the effect of Chrysophanol (CHR) on Alzheimer’s disease. We also attempted to understand the potential...
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Increase in the Level of Orexin Receptor 1 (OX1R) mRNA in the Brain Structures of Rats Prone to Impulsivity in Behavior
Abstract —Orexin and its receptors (OXR) are involved in the mechanisms of pathological craving for alcohol and psychoactive drugs. The orexin system...
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Investigating the effect of cerium oxide nanoparticle on beta-amyloid-induced memory loss
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the loss of nerve cells in the hippocampus region of the brain, leading to...
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Brain distribution and metabolic profiling of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats investigated by UHPLC-HRMS/MS following peripheral administration
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is known to be a tobacco-specific N -nitrosamine and has peripheral carcinogenic properties. It...
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Differential Regulation of Neurotrophic Factors During Pathogenic Tau-Aggregation in a Tau Transgenic Mouse Model for Alzheimer’s Disease: A Protocol for Double-Labeling mRNA by In Situ Hybridization and Protein Epitopes by Immunohistochemistry
Alzheimer’s disease (AD), most tauopathiesTautauopathies, and other neurodegenerative diseases are highly associated to impaired neurotrophin...
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Anti-aging trait of whey protein against brain damage of senile rats
Aging mammalian results in impaired bio-functions and neurological disorders. The current study investigated whether whey protein (WP) syrup...
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TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans
Oral administration of the food-derived antioxidant amino acid ergothioneine (ERGO) results in its efficient distribution in the brain and enhances...
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Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.
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A new approach towards highly sensitive detection of endogenous N-acetylaspartic acid, N-acetylglutamic acid, and N-acetylaspartylglutamic acid in brain tissues based on strong anion exchange monolith microextraction coupled with UHPLC-MS/MS
A novel in-tube solid-phase microextraction coupled with an ultra-high performance liquid chromatography-mass spectrometry method has been...
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In Vivo Evaluation of Self-assembled nano-Saikosaponin-a for Epilepsy Treatment
Saikosaponin-a (SSa) exhibits antiepileptic effects. However, its poor water solubility and inability to pass through the blood–brain barrier greatly...
