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Therapeutic potential of exosome derived from hepatocyte growth factor-overexpressing adipose mesenchymal stem cells in TGFβ1-stimulated hepatic stellate cells
Cirrhosis is a familiar end-stage of multiple chronic liver diseases. The gene-modified mesenchymal stem cells (MSCs) have become one of the most...
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Spatio temporal interdependent calcium and buffer dynamics regulating DAG in a hepatocyte cell due to obesity
Calcium ions (Ca 2+ ) serve as a crucial signaling mechanism in almost all cells. The buffers are proteins that bind free Ca 2+ to reduce the cell’s Ca 2+ ...
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Spike structure of gold nanobranches induces hepatotoxicity in mouse hepatocyte organoid models
BackgroundGold nanoparticles (GNPs) have been extensively recognized as an active candidate for a large variety of biomedical applications. However,...
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In Vitro Properties of Electrospun Composite Fibers Containing Boric Acid and Enhanced with Epidermal Growth Factor for Wound Dressing Applications
The requirements of the wound microenvironment, involving pH regulation, mechanical compatibility with skin, and prevention of bacterial attachment,...
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Acute exposure to gold nanoparticles aggravates lipopolysaccharide-induced liver injury by amplifying apoptosis via ROS-mediated macrophage-hepatocyte crosstalk
BackgroundGold nanoparticles (AuNPs) are increasingly utilized in industrial and biomedical fields, thereby demanding a more comprehensive knowledge...
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ARHGAP18 is Upregulated by Transcription Factor GATA1 Promotes the Proliferation and Invasion in Hepatocellular Carcinoma
Rho GTPase activating protein 18 (ARHGAP18), a member of the RhoGAP gene family that increases GTP hydrolysis and inhibits RhoGTPase, was recently...
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Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer microenvironments, and subsequent signaling through the...
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Liver Regeneration
This review summarizes the functional aspects, cellular kinetics and molecular mechanisms related to liver regeneration. Liver regeneration is a...
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Analysis of CCN Functions in Liver Regeneration After Partial Hepatectomy
The remarkable regenerative capability of the liver has long been appreciated. Upon significant loss of liver tissue, the remnant liver can grow...
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Biomedical Applications of Chitin, Chitosan, Their Derivatives, and Processing By-Products from Fish Waste
The use of natural resources has increased by 254% from 1970 to 2017 globally. Similarly, the consumption of fish and fish products has also gained...
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Modeling and dynamical analysis of the full-length structure of factor XII with zinc
Zinc (II), the second most abundant transition metal in blood, binds to the initiator of the contact pathway, factor XII (FXII). This binding induces...
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Intervention mechanism of marine-based chito-oligosaccharide on acute liver injury induced by AFB1 in rats
Aflatoxin B 1 (AFB 1 ) is extremely hepatotoxic, a causative agent of liver cancer, and can cause symptoms of acute or chronic liver damage....
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Modulation of the growth performance and innate immunity of loaches (Paramisgurnus dabryanus) upon dietary mannan oligosaccharides
Different levels of mannan oligosaccharides (MOs) (100, 300 and 500 mg kg −1 ) were incorporated into a basal diet to formulate three diets, which were...
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Liver-specific delivery of spherical DNA frameworks for alleviation of hepatic ischemic reperfusion injury
DNA nanostructures have long been developed for biomedical purposes, but their controlled delivery in vivo proposes a major challenge for disease...
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Effect of dietary astaxanthin administration on the growth performance and innate immunity of juvenile crucian carp (Carassius auratus)
The present study aims to explore the effects of oral astaxanthin administration on the growth performance and innate immunity of juvenile crucian...
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Effects of Bacillus spp. Mixture on Growth, Immune Responses, Expression of Immune-Related Genes, and Resistance of Nile Tilapia Against Streptococcus agalactiae Infection
The purpose of this study was to evaluate the effect of Bacillus spp. mixture ( Bacillus subtilis TISTR001, Bacillus megaterium TISTR067, and Bacillus...
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Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7
BackgroundA recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular...
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Inhibitory Effect of Cinnamon Essential Oil and Its Active Components on Aspergillus Flavus and Its Toxin
Aflatoxin is a class of secondary metabolites mainly produced by Aspergillus flavus and Aspergillus parasitica. It is highly toxic and carcinogenic....
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Complex of alkylated derivative of 1,4-diazabicyclo[2.2.2]octane with palladium dichloride: synthesis, self-association, and biological activity
A new complex of 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide (cationic surfactant with a bicyclic head group) with palladium dichloride...
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Modification of the Bacterial Metabolites by the Host after Absorption, and Consequences for the Peripheral Tissues’ Metabolism, Physiology, and Physiopathology
After synthesis by the intestinal bacteria, several metabolites are absorbed and metabolized by host tissues giving rise to bioactive co-metabolites....