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Plant Cells: Secondary Metabolite Heterogeneity and Its Manipulation
This chapter proposes the concept of rational manipulation of secondary metabolite heterogeneity in plant cell cultures. The heterogeneity of...
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Combining manipulation of integration loci and secretory pathway on expression of an Aspergillus niger glucose oxidase gene in Trichoderma reesei
Trichoderma reesei ( T. reesei ) is well-known for its excellent ability to secret a large quantity of cellulase. However, unlike the endogenous...
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Additional Gene Therapeutic Platforms
AdditionalTherapeutic gene technologies are summarized here withOligonucleotide active use of CPPs, which are available to restore the missing gene...
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Enhancement of hemostatic properties of Cyclotella cryptica frustule through genetic manipulation
BackgroundThe silicified cell wall of diatoms, also known as frustule, shows huge potential as an outstanding bio-nanomaterial for hemostatic...
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Genetic Manipulation of Crop for Enhanced Food Quality and Nutrition Toward Sustainable Production
Food supply due to the global population growth is the major challenge at present faced by modern society. It is very difficult to feed major...
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Gene Editing Tools for Engineering Beneficial Microorganism in Biofertilizer
The exponentially growing global population has demand for sustainable agriculture practices to increase food production. To achieve higher...
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CRISPR-Based Gene Editing: a Modern Approach for Study and Treatment of Cancer
The development and emergence of clustered regularly interspaced short palindromic repeats (CRISPR) as a genome-editing technology have created a...
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Emerging non-viral vectors for gene delivery
Gene therapy holds great promise for treating a multitude of inherited and acquired diseases by delivering functional genes, comprising DNA or RNA,...
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SynBioStrainFinder: A microbial strain database of manually curated CRISPR/Cas genetic manipulation system information for biomanufacturing
BackgroundMicrobial strain information databases provide valuable data for microbial basic research and applications. However, they rarely contain...
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Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor
BackgroundOviedomycin is one among several polyketides known for their potential as anticancer agents. The biosynthetic gene cluster (BGC) for...
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Impact Study of Gene Expression: Osmotic Control, SOS Response, and Heat Shock Responses
Bacteria live in a dynamic environment with constantly changing temperatures, nutrient levels, and the presence of diverse chemicals. To rapidly...
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Impact of dairy fat manipulation on endothelial function and lipid regulation in human aortic endothelial cells exposed to human plasma samples: an in vitro investigation from the RESET study
PurposeLonger-term intake of fatty acid (FA)-modified dairy products (SFA-reduced, MUFA-enriched) was reported to attenuate postprandial endothelial...
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Diet-Gene Interactions that Regulate Longevity and Diseases
Aging, an almost universal phenomenon, encompasses a gradual yet constant deterioration of the metabolic functions of the body. Aging is...
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Effect of Domain Manipulation in the Staphylococcal Phage Endolysin, Endo88, on Lytic Efficiency and Host Range
The bacteriophage endolysin Endo88 targeting Staphylococcus aureus PS88 consists of the CHAP and Amidase-2 enzymatic domains and one SH3b targeting...
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Carbon Nanomaterials in Drug and Gene Delivery Potential: Focus on Fungal Infections
Fungi are eukaryotic microorganisms, unicellular or multicellular, and several species are responsible for dormant/mild/life-threatening clinical...
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Application of CRISPR-Mediated Gene Editing for Crop Improvement
Plant gene editing has become an important molecular tool to revolutionize modern breeding of crops. Over the past years, remarkable advancement has...
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Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases
The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies...
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Establishing Gene Expression and Knockout Methods in Esteya vermicola CBS115803
Pine wilt disease, which is caused by the nematode Bursaphelenchus xylophilus , is one of the most destructive forest diseases worldwide. Esteya...
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A Universal Gene Expression System for Novel Yeast Species
The current progress in sequencing of genomes and characterization of new species provides an increasing list of yeasts that show interesting...