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Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography
Metal-organic framework (UiO-66-NH 2 )-incorporated organic polymer monolith was prepared by thermal polymerization. By virtue of the superior physical...
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Gold nanoparticles coated with a tetramethylammonium lactobionate ionic liquid for enhanced chiral differentiation in open tubular capillary electrochromatography: application to enantioseparation of β-blockers
A new bilayer chiral stationary phase for use in open tubular capillary electrochromatography (OT-CEC) system is described. Gold nanoparticles were...
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Preparation and Evaluation of a Ferrocenediamide Bridge bis(β-Cyclodextrin)-Bonded Chiral Stationary Phase for HPLC
Ferrocene is a stable metallocene complex with aromatic high-electron π-conjugated system and sandwich structures. We first prepared and...
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Practical Evaluation of Chitosan-Based Chiral Stationary Phase for Pharmaceutical Analysis by High-Performance Liquid Chromatography
In the recent years, the resolution of drug enantiomers has received widespread attention in the medical field. It is of great practical significance...
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Preparation and study of a capillary electrochromatographic column prepared by conjugating β-CD COFs and gold-poly glycidyl methacrylate nanoparticles
A new enantioselective open-tubular capillary electrochromatography (OT-CEC) was developed employing β-cyclodextrin covalent organic frameworks (β-CD...
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Evaluation of deep eutectic solvents chiral selectors based on lactobionic acid in capillary electrophoresis
Recently, deep eutectic solvents (DESs) have attracted considerable interest in analytical chemistry. This work described the enantioseparations of...
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Preparation and evaluation of a perylenediimide bridged bis(β-cyclodextrin) chiral stationary phase for HPLC
A large π-conjugated perylenediimide bridged bis (β-cyclodextrin)-bonded stationary phase (PBCDP) was first prepared and characterized. The chiral...
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Metal organic framework HKUST-1 modified with carboxymethyl-β-cyclodextrin for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs
This work shows that the metal organic framework (MOF) HKUST-1 of type Cu 3 (BTC) 2 (also referred to as MOF-199; a face-centered-cubic MOF containing...
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Recent Advances of Covalent Organic Frameworks for Chiral Separation
C ovalent organic frameworks(COFs), orderly assembled from the building blocks via covalent bonds, are a novel type of porous materials with rich...
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Simultaneous Enantioseparation and Rapid Determination of Atenolol and Amlodipine Besylate by Capillary Electrochromatography
Simultaneous enantioseparation and rapid determination method of atenolol (AN) and amlodipine besylate (AMB) was firstly established using...
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Metal organic framework ZIF-90 modified with lactobionic acid for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs
An in situ zeolite imidazole metal organic framework-90 (ZIF-90) modified capillary was prepared via the method of solvothermal synthesis. The...
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Ionizable Cyclofructan 6-Based Stationary Phases for Hydrophilic Interaction Liquid Chromatography Using Superficially Porous Particles
One of the challenges of hydrophilic interaction liquid chromatography (HILIC) is the development of hydrolytically stable stationary phases. In this...
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Preparation and Evaluation of a Cholesterol Derivatized β-Cyclodextrin-bonded Phase for Achiral and Chiral HPLC
A cholesterol mono-derivatized β -cyclodextrin was synthesized and bonded onto silica gel (SBA-15) to obtain a cholesterol mono-derivatized β -cyclodext...
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A metal organic framework-functionalized monolithic column for enantioseparation of six basic chiral drugs by capillary electrochromatography
Poly(glycidyl methacrylate)-co-(ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths were used as a support to grow a zeolitic imidazolate...
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Recent Advances on Chiral Mobile Phase Additives: A Critical Review
Chirality is one of the fundamental attributes of nature, which exists in different or even completely opposite metabolic, toxicological and...
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A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis
Analytical processes involving sample preparation, separation, and quantifying analytes in complex mixtures are indispensable in modern-day analysis....
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Drug Delivery Systems and Cardiovascular Disease
Clinically, with the treatment of cardiovascular disease in addition to surgery and interventional therapy, drug therapy is also a common means. With...
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Defining a system suitability limit to decide on column deterioration and to facilitate column transfers in chiral supercritical fluid chromatography
The separation of enantiomers is an important requirement during the entire drug life cycle in the pharmaceutical industry. High-performance liquid...
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An organic polymer monolith modified with an amino acid ionic liquid and graphene oxide for use in capillary electrochromatography: application to the separation of amino acids, β-blockers, and nucleotides
The preparation of an organic polymer monolithic column modified with an amino acid ionic liquid and graphene oxide (AAIL-GO) and its application to...
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Cholinesterase and carboxylesterase inhibitors as pharmacological agents
Literature data and authors’ own results on the role of serine hydrolases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), as drug...