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miR-221/222 Promote Endothelial Differentiation of Adipose-Derived Stem Cells by Regulation of PTEN/PI3K/AKT/mTOR Pathway
Adipose-derived stem cells (ADSCs) are a type of adult mesenchymal stem cell that show a repair effect on ischemic tissues owing to their capacity...
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Onion quercetin inhibits vascular endothelial cell dysfunction and prevents hypertension
Onion consumption has been reported to be associated with a lower incidence of myocardial infarction and stroke. Quercetin found in onions may...
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SNORD45A Affects Content of HIF-1α and Promotes Endothelial Angiogenic Function
AbstractTo find out the differentially expressed small nucleolar RNAs (snoRNAs) in corneal neovascularization and their effect on angiogenesis. The...
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Vascular endothelial growth factor-C and its receptor-3 signaling in tumorigenesis
The cancer-promoting ligand vascular endothelial growth factor-C (VEGF-C) activates VEGF receptor-3 (VEGFR-3). The VEGF-C/VEGFR-3 axis is expressed...
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The latest techniques for inducing macrophage differentiation
Macrophages play a prominent role in tissue development, homeostasis, and repair. In addition, their fundamental and well-known functions are...
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miR-92a-3p promotes pulmonary fibrosis progression by regulating KLF2-mediated endothelial-to-mesenchymal transition
Pulmonary fibrosis (PF) is a chronic lung disease that has a poor prognosis and a serious impact on the quality of life of patients. Here, we...
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Exosomes from umbilical cord-derived mesenchymal stem cells combined with gelatin methacryloyl inhibit vein graft restenosis by enhancing endothelial functions
BackgroundThe prevalence of coronary artery disease is increasing. As a common treatment method, coronary artery bypass transplantation surgery can...
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Application of Bioactive Compounds and Biomaterials in Promoting Cell Differentiation, Proliferation, and Tissue Regeneration
Cells, mainly stem cells, possess immense potential in regenerative medicine. Stem cells (SCs) can also play a crucial role in treating diseases due... -
Carmustine-Loaded Liposomal Delivery Effectively Targets Malignant Glioma Cells and Seizes Endothelial Sprouting In vitro
The delivery of chemotherapeutics through the blood-brain barrier remains a challenge for glioblastoma therapeutics. The overdosage of these agents...
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Effect of milk and whey on proliferation and differentiation of placental stromal cells
Fetal bovine serum (FBS), which is widely used in cell culture media, has the potential to cause medical and ethical problems. Here, an experimental...
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Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis
BackgroundBone regeneration is a complex procedure that involves an interaction between osteogenesis and inflammation. Macrophages in the...
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Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury
Spinal cord injury (SCI) is accompanied by loss of Zn 2+ , which is an important cause of glutamate excitotoxicity and death of local neurons as well...
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CircSHOC2 Knockdown Alleviates High Glucose-Induced Vascular Endothelial Cell Pyroptosis via Targeting miR-145/FOXO1 Axis In Vitro Condition
Emerging evidence indicates that pyroptosis participates in the pathogenic process of vascular endothelial cells in cardiovascular system...
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Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway
BackgroundSpinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition poses significant...
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LNX2 involves in the role of ghrelin to promote the neuronal differentiation of adipose tissue-derived mesenchymal stem cells
Adipose tissue-derived mesenchymal stem cells (ADSCs) have promising effects on nerve repair due to the differentiation ability to neural cells....
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Amelioration of C-Reactive Protein and Lectin Like Oxidized Low Density Lipoprotein Receptor Complex Induced Endothelial Dysfunction by Oligomeric Proanthocyanidins
C-reactive protein (CRP) is a well-established biochemical marker for atherosclerosis. Modification of LDL inside the artery wall favors the...
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Endothelial cells-derived exosomes-based hydrogel improved tendinous repair via anti-inflammatory and tissue regeneration-promoting properties
Tendon injuries are common orthopedic ailments with a challenging healing trajectory, especially in cases like the Achilles tendon afflictions. The...
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The Gene Expression Profile in Endothelial Cells Exposed to Mitomycin C
Abstract —The expression of genes involved in DNA repair ( DDB1 , ERCC4 , ERCC5 ), leukocyte adhesion ( VCAM1 , ICAM1 , SELE , SELP ), endothelial...
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Functional extracellular vesicles from SHEDs combined with gelatin methacryloyl promote the odontogenic differentiation of DPSCs for pulp regeneration
BackgroundPulp regeneration is a novel approach for the treatment of immature permanent teeth with pulp necrosis. This technique includes the...
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Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques
Cytosolic estrogen sulfotransferase (SULT1E1) mainly catalyzes the sulfoconjugation and deactivation of estrogens that are known to exert potent...