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Enantiomeric resolution of three profen drugs using direct thin-layer chromatographic method
This study presents the enantiomeric resolution of three profen drugs, viz ., flurbiprofen (FLB), fenoprofen, and zaltoprofen by employing...
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Enantiomeric Phenylpropanoids from Uncaria rhynchophylla
Pairs of enantiomeric phenylpropanoid glycosides and their aglycones, (8R)-stroside A ( 1 ), (8S)-stroside A ( 2 ), (8R)-evofolin B ( 3 ), and...
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Simultaneous evaluation of the enantiomeric and carbon isotopic ratios of Cannabis sativa L. essential oils by multidimensional gas chromatography
Recent times have witnessed an upsurge of interest in hemp and hemp-derived products, as driven by the scientific findings specific to the...
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Theoretical insights into the chiral separation of levobunolol
In this study, we conducted a theoretical investigation to elucidate the chiral recognition mechanisms of polysaccharide-derived stationary phase for...
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Dispersive solid phase extraction based on cross-linked hydroxypropyl β-cyclodextrin polymers for simultaneous enantiomeric determination of three chiral triazole fungicides in water
An efficient method is presented for simultaneous enantioselective determination of three chiral triazole fungicides (namely paclobutrazol,...
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Molecular insights into enantioselective separation of λ-cyhalothrin: a theoretical investigation
λ-Cyhalothrin (CLT), a widely employed pyrethroid insecticide for pest control, is typically marketed as a racemate, akin to many other pesticides....
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Stereoselective analysis and enantioseparation of isoproterenol in spiked human plasma
The present work deals with the synthesis of a novel chiral derivatizing reagent (CDR), namely, N -(4-chloro-6-piperidinyl-[1,3,5]-triazine-2-yl)-D-phe...
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Single ion mobility monitoring (SIM2) stitching method for high-throughput and high ion mobility resolution chiral analysis
Chiral analysis is of high interest in many fields such as chemistry, pharmaceuticals and metabolomics. Mass spectrometry and ion mobility...
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Enantiomeric Resolution of Pidotimod and Its Isomers in Pidotimod Oral Solutions Using Chiral RP-HPLC with Quadrupole Dalton Analyzer Detection
This study aimed to develop and validate a high-performance liquid chromatography system combined with a single-quadrupole Dalton mass detector for...
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New Approaches to Chiral Separation by Means of Capillary Electrophoresis (A Review)
AbstractThe ease of varying the conditions of electrophoretic separation and the possibility of using a wide variety of chiral selectors make the...
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Enantioseparation of 4C-Substituted Pyrrolidin-2-One Derivatives on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases
To extend our previous studies concerning the enantioseparation of 4C-substituted pyrrolidin-2-one derivatives on polysaccharide-based chiral...
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Asymmetric catalytic synthesis of chiral covalent organic framework composite (S)-DTP-COF@SiO2 for HPLC enantioseparations by normal-phase and reversed-phase chromatographic modes
A novel CCOF core–shell composite material ( S )-DTP-COF@SiO 2 was prepared via asymmetric catalytic and in situ growth strategy. The prepared ( S )-DTP-COF@SiO...
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Enantioresolution of three β-blockers using l-glutamic acid as chiral selector by thin-layer chromatographic methods
Stereoselective dependence of active pharmaceutical ingredients for their pharmacokinetics inspired the researchers to develop new analytical methods...
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Determination of the Enantiomeric Purity of Solriamfetol by High-Performance Liquid Chromatography in Polar Organic Mode Using Polysaccharide-Type Chiral Stationary Phases
Solriamfetol is a novel FDA approved enantiopure drug used for the treatment of excessive sleepiness associated with narcolepsy or obstructive sleep...
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Enantiomeric separation of quorum sensing autoinducer homoserine lactones using GC-MS and LC-MS
Homoserine lactones (HSLs) are signaling molecules synthesized by Gram-negative bacteria in order to communicate in a process termed “quorum...
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Enzymatic synthesis of mono- and trifluorinated alanine enantiomers expands the scope of fluorine biocatalysis
Fluorinated amino acids serve as an entry point for establishing new-to-Nature chemistries in biological systems, and novel methods are needed for...
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Biocatalytic, enantioenriched primary amination of tertiary C–H bonds
Intermolecular functionalization of tertiary C–H bonds to construct fully substituted stereogenic carbon centres represents a formidable challenge:...
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β-Cyclodextrin-based chiral nanocomposite for thin-layer chromatographic detection of enantiomers of fluoxetine
Enantioselective analysis or separation is very essential for improved therapeutic effects of drugs as the pure enantiomeric drug formulations...
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A simple and cost-effective synthesis of sulfated β-cyclodextrin and its application as chiral mobile phase additive in the separation of cloperastine enantiomers
A simple and cost-effective method for the synthesis of sulfated β-cyclodextrin, one of the most widely used chiral mobile phase additives, using...
