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Affinity-based isolation of extracellular vesicles and the effects on downstream molecular analysis
Extracellular vesicles (EVs) are transport vesicles with diameters ranging from 30 to 1000 nm, secreted by cells in both physiological and...
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Downstream Processing in Marine Biotechnology
Downstream processing is one of the most underestimated steps in bioprocesses and this is not only the case in marine biotechnology. However, it...
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Downstream Processing for Bio-product Recovery and Purification
The recovery and purification of various bio-products or biomolecules, notably therapeutics, from sustainable materials, e.g., plant or animal tissue...
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Downstream Purification of the Biopharmaceutical Drug Substance
The upstream production process has been designed to yield the intended biopharmaceutical. But the upstream design carries with it a complex impurity...
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Aptamer-based Membrane Protein Analysis and Molecular Diagnostics
Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular activities. Analysis of membrane proteins is...
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Cost-Effective Downstream Processing of Algal Biomass for Industrial-Scale Biofuels Production
Presently, the availability of limited fossil fuel resources and environmental pollution are significant international concerns. Algae have...
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Scale-Up of Protein Purification: Downstream Processing Issues
Large-scale chromatography operations continue to occupy the central position in the overall strategy for downstream processing and purification of...
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Identification of Novel PI3Kα Inhibitor Against Gastric Cancer: QSAR-, Molecular Docking–, and Molecular Dynamics Simulation–Based Analysis
Gastric cancer (GC) is a malignant tumor with global incidence and death ranking fifth and fourth, respectively. GC patients nevertheless have a poor...
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Critical Quality Attributes of Biomass that Affect Downstream Conversion
Biomass exists in nature as lignocellulosic or non-lignocellulosic forms. For more than five decades, renewable biomass has been in the spotlight...
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Downstream process development of biobutanol using deep eutectic solvent
Biobutanol is produced from lignocellulose fermentation. Owing to the abundance of this feedstock and the similarities between the properties of...
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Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications
The non-structural protein 5 (NS5) is the most conserved protein among flaviviruses, a family that includes the dengue virus. It functions both as an...
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Hierarchical Molecular Graph Self-Supervised Learning for property prediction
Molecular graph representation learning has shown considerable strength in molecular analysis and drug discovery. Due to the difficulty of obtaining...
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Large-scale crystallization as an intermediate processing step in insulin downstream process: explored advantages and identified tool for process intensification
The rising global prevalence of diabetes and increasing demand for insulin, calls for an increase in accessibility and affordability of insulin drugs...
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Systematic analysis, aggregation and visualisation of interaction fingerprints for molecular dynamics simulation data
Computational methods such as molecular docking or molecular dynamics (MD) simulations have been developed to simulate and explore the interactions...
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Substrates of Opposite Polarities and Downstream Processing for Efficient Production of the Biosurfactant Mannosylerythritol Lipids from Moesziomyces spp.
Biosurfactants can replace fossil-driven surfactants with positive environmental impacts, owing to their low eco-toxicity and high biodegradability....
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Molecular docking and molecular dynamics simulation decoding molecular mechanism of EDCs binding to hERRγ
ContextHuman estrogen-related receptor γ (hERRγ) is a key protein involved in various endocrines and metabolic signaling. Numerous environmental...
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Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular Docking and Molecular Dynamics
Curcumin, a phenolic compound derived from turmeric, has demonstrated anti-tumor properties in preclinical models of various cancers. However, the...
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Monitoring Methods for Anaerobic Digestion of Food Waste: Physicochemical and Molecular Analysis
Anaerobic digestion (AD) is a process in which organic matter such as food waste is degraded and converted into methane, a renewable energy source....
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Molecular recording of calcium signals via calcium-dependent proximity labeling
Calcium ions serve as key intracellular signals. Local, transient increases in calcium concentrations can activate calcium sensor proteins that in...
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Protein purification strategies must consider downstream applications and individual biological characteristics
BackgroundProteins are used as reagents in a broad range of scientific fields. The reliability and reproducibility of experimental data will largely...
