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Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy
DNAzyme-based gene therapy faces some challenges including cell penetration, activity limitation, and co-delivery functions. Self-assembled DNA...
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Construction and Application of DNAzyme-based Nanodevices
T he development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on....
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Exonuclease III-propelled DNAzyme walker: an electrochemical strategy for microRNA diagnostics
MicroRNA detection is crucial for early infectious disease diagnosis and rapid cancer screening. However, conventional techniques like reverse...
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High-affinity truncated aptamers for detection of Cronobacter spp with magnetic separation-assisted DNAzyme-driven 3D DNA walker
After optimizing the original aptamer sequence by truncation strategy, a magnetic separation-assisted DNAzyme-driven 3D DNA walker fluorescent...
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Split-DNAzyme cooperating primer exchange reaction for sensitive miRNA detection
Sensitive quantification of microRNA (miRNA) plays a crucial role in early diagnosis and precise therapy of osteosarcoma. Herein, we build a...
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CRISPR-Cas13a-Triggered DNAzyme Signal Amplification-Based Colorimetric miRNA Detection Method and Its Application in Evaluating the Anxiety
The development of a bio-sensing strategy based on CRISPR/Cas that is exceptionally sensitive is crucial for the identification of trace molecules....
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A DNAzyme-assisted near-infrared upconversion fluorescence sensing strategy for ultra-sensitive, and rapid quantification of uranyl
Presented is an infrared-induced sensor constructed of upconversion nanoparticles and DNAzyme for ultra-sensitive, and rapid detection of uranyl...
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A novel binding-induced DNAzyme motor triggered by survivin mRNA
The accurate and sensitive detection of survivin mRNA is of great significance for cancer diagnosis and treatment. However, limited by the...
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Caging-Decaging Strategies to Realize Spatiotemporal Control of DNAzyme Activity for Biosensing and Bioimaging
DNAzymes with RNA-cleaving activity have been widely used as biosensing and bioimaging tools for detection of metal ions. Despite the achievements,...
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Target-mediated competitive hybridization of hairpin probes for kanamycin detection based on exonuclease III cleavage and DNAzyme catalysis
Based on aptamer recognition and target-mediated competitive hybridization of hairpin probes, we developed a fluorescence sensor for kanamycin (KAN)...
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Responsive Cysteine-Lighted Silver Nanoclusters Regulated by Highly Catalytic G-Quadruplex DNAzyme for Ultrasensitive Detection of Salmonella Typhimurium
Cysteine (Cys) can rapidly and sensitively react with 12 polycytosine-templated silver nanoclusters (polyC 12 -AgNCs) via the formation of Ag–S bond...
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DNAzyme signal amplification based on Au@Ag core–shell nanorods for highly sensitive SERS sensing miRNA-21
Here, we developed a surface-enhanced Raman scattering (SERS) sensor based on functionalized Au@Ag core–shell nanorods (Au@Ag NRs) and cascade...
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Signal-on fluorescent sensing strategy for Pb2+ detection based on 8–17 DNAzyme-mediated molecular beacon-type catalytic hairpin assembly circuit
Based on a Pb 2+ -specific 8–17 DNAzyme-induced catalytic hairpin assembly (CHA), a simple signal-on fluorescence strategy for lead ion detection was...
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Exo-III Enzyme and DNAzyme-Assisted Dual Signal Recycles for Sensitive Analysis of Exosomes by Using Personal Glucose Meter
Exosome plays a crucial role in regulating intercellular communication during atherosclerosis development. However, sensitive and portable exosome...
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DNAzyme-based faithful probing and pulldown to identify candidate biomarkers of low abundance
Biomarker discovery is essential for the understanding, diagnosis, targeted therapy and prognosis assessment of malignant diseases. However, it...
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Electrochemical microRNA detection based on catalytic deposition of G-quadruplex DNAzyme in nanochannels
Abnormal expression and functioning of microRNAs in the immune system are frequently linked to various cancers. Our previous work demonstrated a...
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Signal-enhanced visual strand exchange amplification detection of African swine fever virus by the introduction of multimeric G-quadruplex/hemin DNAzyme
African swine fever virus (ASFV) causes hemorrhagic infectious disease in pigs with a fatality rate of nearly 100%. In this study, we developed a...
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DNAzyme-controlled plasmonic coupling for SERS-based determination of Salmonella typhimurium using hybridization chain reaction self-assembled G-quadruplex
A facile and rapid SERS strategy for S. typhimurium detection based on hybridization chain reaction (HCR) self-assembled G-quadruplex DNAzyme (GQH...
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