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DeSIDE-DDI: interpretable prediction of drug-drug interactions using drug-induced gene expressions
Adverse drug-drug interaction (DDI) is a major concern to polypharmacy due to its unexpected adverse side effects and must be identified at an early...
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MDDI-SCL: predicting multi-type drug-drug interactions via supervised contrastive learning
The joint use of multiple drugs may cause unintended drug-drug interactions (DDIs) and result in adverse consequence to the patients. Accurate...
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Recent development of machine learning models for the prediction of drug-drug interactions
Polypharmacy, the co-administration of multiple drugs, has become an area of concern as the elderly population grows and an unexpected infection,...
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Mechanism of Effect of Non-Reactive Polyhedral Oligomeric Silsesquioxane Nanostructures on HTPB-Based Polyurethane Network Formation: A Rheokinetic Analysis
This study explored the influence of non-reactive POSS nanostructures (Octa isobutyl silsesquioxane (OIBS) and Octa phenyl silsesquioxane (OPS)) on...
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Machine learning to predict metabolic drug interactions related to cytochrome P450 isozymes
Drug–drug interaction (DDI) often causes serious adverse reactions and thus results in inestimable economic and social loss. Currently, comprehensive...
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Simulation and experimental study on the incompatibility issue between ADN and isocyanate
ContextSince solid composite propellants are composed of a high percentage of oxidizers, the search for green oxidizers such as ammonium dinitramide...
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Determination of iron species in food samples with dual direct immersion single-drop microextraction followed by graphite furnace atomic absorption spectrometry
A novel procedure of dual direct immersion single-drop microextraction (DDI-SDME) was developed for the sequential separation and preconcentration of...
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Influence of Three-Spin Groups on the Primary Echo in Linear Polymers with Free Ends
AbstractBased on the previously developed theory of the free induction decay and spin echo, the theory of the primary echo in flexible-chain polymers...
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Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method
The influence of genetic polymorphism of metabolic enzymes on drug–drug interactions (DDI) should be thoroughly investigated owing to its remarkable...
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Computational screening for investigating the synergistic regulatory potential of drugs and phytochemicals in combination with 2-deoxy-D-glucose against SARS-CoV-2
COVID-19 disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was declared a global pandemic by the World Health...
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Instrumental neutron activation analysis by utilizing pneumatic carrier facility at Dhruva reactor for estimation of minor and trace elements in antidiabetic ayurvedic formulations
Ayurvedic formulations could be one of the good options for controlling diabetes mellitus. Present study was undertaken to determine minor and trace...
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Current Status in PBPK Modeling
Physiologically based pharmacokinetic (PBPK) modeling is a mathematical approach that integrates the intrinsic pharmacokinetic properties of a drug...
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An Application of Dipole–Dipole Interaction Model in Stacking Dimers Including Protonated Arginine Residue
AbstractThe dipole–dipole interaction model is further developed to predict the stacking interaction between the protonated arginine residue and...
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Effect of powdering on critical water activity estimate from dynamic dewpoint isotherm of a crispy starch-based snack: a case study with fish cracker
The moisture sorption isotherm (MSI) and critical water activity ( a w , crit ) of a dry food determine the moisture barrier properties required of...
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Visualization of CO2 electrolysis using optical coherence tomography
Electrolysers offer an appealing technology for conversion of CO 2 into high-value chemicals. However, there are few tools available to track the...
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Investigation on in-cylinder and in-intercooler thermodynamic properties of miniature multi-stage reciprocating compressor with insufficient inter-stage volumes
Miniature multi-stage reciprocating compressor is the core component in the on-board continuous high-pressure gas supply system. Intercoolers play an...
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Synthesis of Long-chain Paraffins over Bimetallic Na–Fe0.9Mg0.1Ox by Direct CO2 Hydrogenation
Direct CO 2 hydrogenation into long-chain hydrocarbons over iron catalysts is considered the most promising approach to mitigate global warming...
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On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body
Contending with variability in drug exposure and effect in disease populations requires patient characterization for changes in drug metabolism and...
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Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof
The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19...
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The impact of a metallic partial-flow particulate filter on diesel engine combustion and emission characteristics using palm oil biodiesel blends
Reducing particulate emissions from diesel engines pose a significant challenge in develo** countries due to increasingly stringent regulations for...
