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Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Exploiting nature’s catalysts for non-natural transformations that are inaccessible to chemocatalysis is highly desirable but challenging. On the one...
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Stereoselective conjugate cyanation of enals by combining photoredox and organocatalysis
Precise control over the selectivity of a reaction is a fundamental target. While great advances have been obtained in achieving stereocontrol, the...
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Development of bovine elastin/tannic acid bioactive conjugate: physicochemical, morphological, and wound healing properties
Elastin is a functional protein of the dermal extracellular matrix and a critical component of skin wound healing. In severe wounds, skin cells do...
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Conjugate electrospun photochromic adjustable magnetic bifunctional Janus-structure nanofibers array
Using conjugate electrospinning technology to prepare Janus-structure nanofiber array and endow it with multifunctional characteristics is a very...
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Synthesis and neuroprotective activity of a (–)-cytisine-isoflavone conjugate
N -Methylene conjugate of (–)-cytisine and (4',7-dihydroxy-3'-methoxy)isoflavone, extracted from Sophora alopecuroides L., has been designed and...
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Development of a novel glycoengineering platform for the rapid production of conjugate vaccines
Conjugate vaccines produced either by chemical or biologically conjugation have been demonstrated to be safe and efficacious in protection against...
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Role of structural components of the 2-methoxyestradiol—chlorambucil conjugate in microtubule stabilization
The conjugate of 2-methoxyestradiol, a ligand for the cell protein tubulin, with two molecules of chlorambucil, known as a DNA-alkylating agent, is...
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Degradation of poly(conjugated ester)s using a conjugate substitution reaction with various amines and amino acids in aqueous media
We previously reported the quantitative main-chain scission reaction of polymers by a conjugate substitution reaction in aqueous ammonia, although...
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Synthesis of a Thioglucoside and Its Tetracyclic Conjugate Based on 6-Bromo-1,4-naphthoquinone Derivatives
AbstractA bromine-containing naphthoquinone–carbohydrate conjugate has been synthesized for the first time by intramolecular condensation of...
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Pimonidazole-alkyne conjugate for sensitive detection of hypoxia by Cu-catalyzed click reaction
Hypoxia is involved in various diseases, such as cancers. Pimonidazole has often been used as the gold-standard marker to visualize hypoxic regions....
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Glutathione-Capped ZnS Quantum Dots-Urease Conjugate as a Highly Sensitive Urea Probe
AbstractQuantum dots (QDs) possess characteristic chemical and optical features. In this light, ZnS QDs capped with glutathione (GSH) were...
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Michael Addition
Also known as conjugate addition, Michael addition is the 1,4-addition of a nucleophile to an α,β-unsaturated system.
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Synthesis and Inhibitory Activity of Atorvastatin Conjugate with a Branched Asialoglycoprotein Receptor Ligand Containing Three N-Acetyl-d-galactosamine Residues
AbstractA novel atorvastatin conjugate was synthesized by a multistep procedure, using a branched N -acetylgalactosamine ligand for...
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Hybrid random batch idea and nonlinear conjugate gradient method for accelerating charged polymer dynamics simulation
AbstractIn this paper, we present a novel energy minimization approach (called R-NCG) that combines a random batch idea with a nonlinear conjugate...
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Preparation of a Klebsiella pneumoniae conjugate nanovaccine using glycol-engineered Escherichia coli
BackgroundEngineered strains of Escherichia coli have been used to produce bioconjugate vaccines using Protein Glycan Coupling Technology (PGCT)....
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A meshless numerical study of conjugate mixed convection of non-Newtonian nanofluids in an enclosure using non-homogeneous model
The present study deals with the conjugate mixed convection of a non-Newtonian nanofluid in an enclosure with a left thick side wall. We adopt...
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Enantioselective synthesis of tetrasubstituted allenes via addition/arylation tandem reaction of 2-activated 1,3-enynes
We report the development of a new class of multifunctional chiral guanidine/Pd(0) catalyst system for 1,4-addition/arylation tandem reaction. A...
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Stereochemistry of Addition Reactions
Addition reactions are of three types, viz., electrophilic addition reactions, nucleophilic addition reactions and free radical addition reactions....
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A New Sesquiterpenoid-Geranylbenzene Conjugate from the Roots of Lindera chunii
Lindechunisin A, a new sesquiterpenoid-geranylbenzene conjugate, was isolated from the roots of Lindera chunii. The structure of this compound was...
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TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
BackgroundPancreatic cancer is a highly aggressive malignancy with limited treatment options and a poor prognosis. Trophoblast cell surface antigen 2...
