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Chemical Genomics: From Target Protein to Small Molecule Drug
In forward chemical genomics, agents are tested on cells to induce a biological change (phenotype). The target of the drug is then determined. In...
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Polymer Genomics
Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...
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Genomics of Bioenergy Crops
As the world population is increasing day by day, thus, the need to produce large amount of energy is also increasing. Therefore, the hunt for a...
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Unveiling Microbial Chemical Interactions Based on Metabolomics Approaches
Microorganisms are ubiquitous in diverse habitats and studying their chemical interactions with the environment and comprehend its complex relations...
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Enhancing Spinacia oleracea L. Breeding in the Post Genomics Era
Spinach is a popular cool-season green vegetable that is eaten all around the world. Spinach is a highly heterozygous dioecious, wind-pollinated...
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Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux
Pyrvinium is a quinoline-derived cyanine dye and an approved anti-helminthic drug reported to inhibit WNT signaling and have anti-proliferative...
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Chemical Genetics: Validation of the Drug Target by Elucidation of the Signaling Pathway
As explained in Sect. 4.3 , chemical genetics is the oldest subdiscipline of chemical biology and has long...
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Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
Medicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical...
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Smart Plant Breeding for Potato in the Post-genomics Era
Ceaseless development of plant breeding and genetic endeavors have resulted in accidental plant selection, successive harvest training plus urge of...
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Raman Spectroscopy for Tracking the Polysaccharides Chemical Composition and β-Carotene Accumulation of Microalgae Food Source
Raman spectroscopy is a detection method that combines Raman spectroscopy and confocal microanalysis. It can provide chemical fingerprint information...
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Wearable chemical sensors for biomarker discovery in the omics era
Biomarkers are crucial biological indicators in medical diagnostics and therapy. However, the process of biomarker discovery and validation is...
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From Genomic Research to Chemical Biology
Another reason why the development of new drugs is difficult is grounded in genomic research. The genome codes for about 23,000 genes, that is, sites...
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Chemical Biology: Addressing New Drug Targets
Despite successes in genome research, the development of new drugs remains a challenge. The central problem is that the majority of genes and their...
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Machine learning and comparative genomics approaches for the discovery of xylose transporters in yeast
BackgroundThe need to mitigate and substitute the use of fossil fuels as the main energy matrix has led to the study and development of biofuels as...
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Chemical approaches to cryopreservation
Cryopreservation of cells and biologics underpins all biomedical research from routine sample storage to emerging cell-based therapies, as well as...
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Role of Omics and Its Integration into Modern-Day Technologies: Identification in Production of Industrially Relevant Bioproducts
The term “omics” is derived from a Greek word meaning “for every” or “all”. Omics technologies, encompasses genomics, transcriptomics, proteomics,...
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Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries
In this chapter, different encoding strategies for DNA- or PNA-encoded chemical libraries are presented. In general, DNA encoding can be...
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In-silico target prediction by ensemble chemogenomic model based on multi-scale information of chemical structures and protein sequences
Identification and validation of bioactive small-molecule targets is a significant challenge in drug discovery. In recent years, various in-silico ...
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DNA as a universal chemical substrate for computing and data storage
DNA computing and DNA data storage are emerging fields that are unlocking new possibilities in information technology and diagnostics. These...
