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Advances in the optimization of central carbon metabolism in metabolic engineering
Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic...
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Isolation of a pentadienyl-type radical featuring a central secondary carbon
Stable tertiary R 3 C· carbon radicals have been known since Gomberg’s pioneering discovery of the triphenylmethyl radical more than a century ago. In...
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Complex regulation in a Comamonas platform for diverse aromatic carbon metabolism
Critical to a sustainable energy future are microbial platforms that can process aromatic carbons from the largely untapped reservoir of lignin and...
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The Metabolism of Respiring Carbon Sources by Dekkera bruxellensis and Its Relation with the Production of Acetate
Dekkera bruxellensis has been studied for several aspects of its metabolism over the past years, which has expanded our comprehension on its...
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Metabolic Engineering of Central Carbon Metabolism of Bacillus licheniformis for Enhanced Production of Poly-γ-glutamic Acid
Poly-γ-glutamic acid (γ-PGA) is an anionic polymer with wide-ranging applications in the areas of medicine, light chemical industry, wastewater...
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Optimization of trans-4-hydroxyproline synthesis pathway by rearrangement center carbon metabolism in Escherichia coli
Backgroundtrans -4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production...
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Carbon
We take a wide-ranging look at “organic chemistry,” the study of carbon-containing compounds. Since carbon is central to the structure and function...
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Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess
BackgroundEscherichia coli adapted to carbon-limiting conditions is generally geared for energy-efficient carbon utilization. This includes also the...
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Development of a Standardized MRM Method for the Quantification of One Carbon Metabolism Enzymes
One-carbon metabolism (1CM) plays a central role in liver physiology, being the source of essential metabolites such as S-adenosylmethionine, the...
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The impact of high voltage electrostatic field on the storage quality and metabolism of Chinese kale
In response to the current diversity of vegetables and the limitations of storage and preservation techniques caused by their propensity for spoilage...
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Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism
Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as the hub of oxidative metabolism where sugars, fats, and...
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Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum
BackgroundDiatoms are well known for high photosynthetic efficiency and rapid growth rate, which are not only important oceanic primary producer, but...
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Trehalose alleviates high‐temperature stress in Pleurotus ostreatus by affecting central carbon metabolism
BackgroundTrehalose, an intracellular protective agent reported to mediate defense against many stresses, can alleviate high-temperature-induced...
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Multi-omics analyses revealed key factors involved in fluorescent carbon-dots-regulated secondary metabolism in Tetrastigma hemsleyanum
BackgroundLuminescent nanomaterials (LNMs), especially newly-exploited fluorescent carbon-dots (CDs), have demonstrated promising candidates for...
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Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling
Anaerobic microbial metabolism drives critical functions within global ecosystems, host–microbiota interactions, and industrial applications, yet...
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Control of Fluxes Towards Antibiotics and the Role of Primary Metabolism in Production of Antibiotics
Yield improvements in antibiotic-producing strains have classically been obtained through random mutagenesis and screening. An attractive alternative...
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Molecular Hydrogen (H2) Metabolism in Microbes: A Special Focus on Biohydrogen Production
In recent years, biohydrogen production (produced from renewable sources either biologically or photo-biologically) has attracted substantial...
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Biochemistry of Secondary Metabolism of Fungi
Fungi, eukaryotic organisms with a kingdom of their own, include microorganisms from moulds and yeasts to the most known and appreciated mushrooms....
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Recent advances of microbial metabolism analysis: from metabolic molecules to environments
Microbial metabolism analysis is of great significance to the biosynthesis industries and the diagnosis and treatment of infectious diseases caused...
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A metal-catalysed functional group metathesis approach to the carbon isotope labelling of carboxylic acids
The distribution, metabolism and ultimate fate of molecules within the body is central to the activity of pharmaceuticals. However, the introduction...
