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Study on the S239D/I332E mutation effect on the kinetics of Fc–Fc receptor binding through transition complex theory
The S239D/I332E mutation in both chain A and chain B of Fc is widely employed to enhance the binding affinity of Fc to its receptor (FcγRIIIa)....
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Computational Protein Binding
Why it is important to know this material? The computational approach to protein binding has become a crucial methodology in drug design and...
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Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3
Ternatin-family cyclic peptides inhibit protein synthesis by targeting the eukaryotic elongation factor-1α. A potentially related cytotoxic natural...
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Protein-Ligand Interactions and Binding
Why it is important to know this material? Protein binding is implied in all biological mechanisms, and the definition of quantitative models and...
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Kinetics and Dynamics of Sorption of the Glucose Target Molecule by a Molecularly Imprinted Polymer
AbstractThe effect of imprinting of a polymer matrix based on ethylene glycol dimethacrylate on the kinetics and dynamics of binding of the glucose...
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pH-Dependent binding energy-induced inflection-point behaviors for pH-universal hydrogen oxidation reaction
The kinetics of hydrogen oxidation reaction (HOR) declines with orders of magnitude when the electrolyte varies from acid to base. Therefore,...
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Effect of eutectic formulation on photodegradation kinetics of ornidazole in aqueous state: predicted interaction and molecular binding in docking studies
The sensitivity of ornidazole towards UV light is one of the most crucial causes in the significant reduction of the therapeutic efficacy. The effect...
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Kinetics of Microbial Growth, Substrate Consumption, and Product Formation
Microbial activities could be utilized for the production of secondary metabolites such as antibiotics, growth hormones, etc. The microorganisms can...
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Chemical Kinetics
Pesticides and herbicides that are used to enhance crop production on the world’s farms are the application focus for this chapter on the rates and...
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Evaluation of the Molecular Interaction Between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance
CCN proteins are known to bind to various growth factors, cytokines, and membrane proteins. Since these bindings are closely involved in the function...
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Software for Predicting Binding Free Energy of Protein–Protein Complexes and Their Mutants
Protein–protein binding affinity prediction is important for understanding complex biochemical pathways and to uncover protein interaction networks....
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Trinuclear europium complexes with a tripodal ligand: formation kinetics in acetonitrile
Here we report on the characterizations (mass spectrometry and NMR) and kinetic investigations related to the formation of trinuclear complexes [Eu 3 L ]
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Chemical Equilibria and Kinetics
Most quantum mechanical applications (Chaps. 12 , 14...
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Kinetics of CPPs Cellular Uptake
In this Chapter, the availableStimulations data on multistep internalization of CPPs and for CPP-cargoCargo conjugates with the hope that these will...
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Determining the Binding Kinetics of Peptide Macrocycles Using Bio-Layer Interferometry (BLI)
Bio-Layer Interferometry (BLI) enables the detection and characterization of molecular interactions in real-time without the hassle and interference...
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SARS-CoV-2S-Protein–Ace2 Binding Analysis Using Surface Plasmon Resonance
Surface plasmon resonance (SPR) allows for the label-free determination of the binding affinity and rate constants of bimolecular interactions. Here,...
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Generation of DNA oligomers with similar chemical kinetics via in-silico optimization
Networks of interacting DNA oligomers are useful for applications such as biomarker detection, targeted drug delivery, information storage, and...
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Photoelectrochemical charge kinetics and transfer mechanisms of organic curcumin (turmeric) photoelectrodes
This work presents a novel study on the water-splitting behavior of organic curcumin (C), based on its photoelectrochemical activity. The...
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Structural and Biochemical Studies on Klebsiella Pneumoniae Enoyl-ACP Reductase (FabI) Suggest Flexible Substrate Binding Site
Klebsiella pneumoniae , a bacterial pathogen infamous for antibiotic resistance, is included in the priority list of pathogens by various public...
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Intrinsic Fluorescence Kinetics in Proteins
Detecting changes in the intrinsic fluorescence of proteins enables non-invasive monitoring of their biological activities. Here, we present the...