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Exploring the Therapeutic Potential of Wild Edible Mushrooms: Safety Evaluation and Isolation of Antimycobacterial Sterols from Afrocantharellus platyphyllus (Heinem.) Tibuhwa
PurposeAfrocantharellus platyphyllus (Heinem.) Tibuhwa (family Cantharellaceae) is a wild mushroom that is used for food and in the management of...
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Design, Synthesis, and Computational Characterization of Interesting Schiff Base Scaffolds as Antibacterial, Antimycobacterial, and Antifungal Agents
AbstractA series of ( E )-1-(3/4-{[( E )-(2-chloroquinolin-3-yl)methylidene]amino}phenyl)ethan-1-one oximes 3a – 3j have been designed and synthesized by...
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Synthesis of 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol as potential antimycobacterial agents
Resistance to antibiotic drugs has directed global health security to a life-threatening situation due to mycobacterial infections. In search of a...
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Bioassay-guided isolation of antimycobacterial substances from the traditionally used lichen Cladonia pyxidata (L.) Hoffm.
The aim of the present study is to provide a scientific rationale for the folklore usage of Cladonia pyxidata (L.) Hoffm. in treating tuberculosis...
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Synthesis and Antitubercular Activity of New 5-Alkynyl Derivatives of 2-Thiouridine
AbstractNew efficient mycobacterial inhibitors based on 5-substituted 2-thiouridine derivatives have been described. A series of new...
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In vitro antimycobacterial studies of flavonols from Bauhinia vahlii Wight and Arn
Mycobacterial infections and fast-growing strains are increasing globally with 8 million new cases and 1.8 million fatalities per annum worldwide....
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Analgesic and Antidepressant Activity of 8-Substituted Harmine Derivatives
The present study describes the synthesis of a novel type of harmine derivatives, containing substituent at the C-8 position and their...
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Experimental and computational studies of an antiplasmodial derivative of allantoin; antimycobacterial essential oil from Cordia batesii WERNHAM (Boraginaceae)
BackgroundChemical and pharmacological investigations were performed on the stems of Cordia batesii (Boraginaeae); chemical studies included quantum...
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Discovery of Novel Substituted N-Methylpyrazole Scaffolds as MmpL3 Inhibitors
AbstractA series of novel pyrazole-based MmpL3 inhibitor were designed and synthesized. The new compounds were studied by spectral method,...
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Synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-and N-(2-aminoethanesulfonyl)-(S)-glutamic acids
The approaches to the synthesis of purine conjugates with N -(4-aminobenzenesulfonyl)-( S )-glutamic acid and N -(2-ammoethanesulfonyl)-( S )-glutamic acid...
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Synthesis of Benzothiazole and Pyrimidine Based Fused Derivatives and Their Biological Evaluation
AbstractIn the present study a series of ethyl 4-(substituted)-2-methyl-4 H -benzo[4,5]thiazolo[3,2- a ]pyrimidine-3-carboxylate and ethyl...
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Recent developments on the synthesis of copper and cobalt-Schiff base complexes and their assessment as anti-tuberculosis drugs
The World Health Organization has identified tuberculosis (TB) as one of the major global health hazards and designated it as a “global public health...
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Polymer Cu2+ and Ag+ furancarboxylate complexes with 4,4’-bipyridine: synthetic approaches, structure, thermal behavior, and biological activity
Polymer complexes of the composition {[Cu 2 (fur) 4 (bpy)] n • n MeOH} ( 1 ) and {[Ag 3 (fur)(bpy) 4 ] n •2 n fur·13.5nH 2 O} ( 2 ) were synthesized by the reactions of...
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New Drugs in Synthesis Research for Tuberculosis
Mycobacterium tuberculosis is the bacteria which causes tuberculosis. It is a significant public health concern worldwide. An estimated ten million...
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Novel 1,3-Indenedione-Based Azo Dyes: Synthesis, Characterization, Solvatochromic UV-Vis Absorption Study, and Biological Activity
AbstractIn this work, we reported the synthesis of novel indanedione-based azo dyes by a conventional diazo coupling reaction at 0–5°C. The...
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Convenient and green synthesis of novel 1,2,5-trisubstituted benzimidazole compounds and their antibacterial activity evaluation
An efficient synthesis of 1,2,5-trisubstituted benzimidazoles was explored under microwave irradiation. Twenty novel 1,2,5-trisubstituted...
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Insights into synthesis, reactivity, and biological activity of N-isoindoline-1, 3-diones heterocycles: a systematic literature review
This review paper provides a comprehensive overview of recent advancements in the synthesis, reactivity, and applications of N -isoindoline-1,3-dione...
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Synthesis of some novel isatin-thiazole conjugates and their computational and biological studies
The present work describes the synthesis of novel 3-[2-(5-phenyl-1,3-thiazol-2-yl)hydrazinyl]-1,3-dihydro-2H-indol-2-one derivatives 4(a-h) and the...
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Synthetic Approaches, Biological Activities, and Structure–Activity Relationship of Pyrazolines and Related Derivatives
It has been established that pyrazolines and their analogs are pharmacologically active scaffolds. The pyrazoline moiety is present in several...
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Fe3O4@PEG Core-Shell Nanosphere Anchored and Stabilized by Nickel Complex on Murexide: Green Synthesized Nanocatalyst with Super Catalytic Activity for Synthesize of Benzothiazole Derivatives
The recent advances in the green-based design and synthesis of core-shell nanostructures have always been an intriguing arena to scientists due to...
