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Repurposing Amphotericin B: anti-microbial, molecular docking and molecular dynamics simulation studies suggest inhibition potential of Amphotericin B against MRSA
Amphotericin B (AMPH) is an anti-fungal drug and this study, for the first time as best of our knowledge, reports the repurposing of the Amphotericin...
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Synergistic activity of gold nanoparticles with amphotericin B on persister cells of Candida tropicalis biofilms
AimThe antifungal activity was studied on sessile and persister cells (PCs) of Candida tropicalis biofilms of gold nanoparticles (AuNPs) stabilized...
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Antifungal Macrocycle Antibiotic Amphotericin B—Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice
Abstract —This review is devoted to a broad analysis of the results of studies of the effect of macrocyclic antifungal polyene antibiotic amphotericin...
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Synthesis of Amphotericin B Conjugated Chitosan Nanomaterial From Fish Scales and Evaluation of its Antifungal Activity
Nanotechnology deals with the new facets of materials described as nanomaterials which have interesting attributes like large surface area to volume...
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UV–Vis spectrophotometry for rapid and specific quantification of amphotericin B: analytical method validation for ex vivo and in vivo studies in the development of nanoemulsion-incorporated thermosensitive gel
Amphotericin B (AmB) is the first-line drug used for the treatment of cryptococcal meningitis (CM). AmB has poor gastrointestinal permeability due to...
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Enhancing the production of amphotericin B by Strepyomyces nodosus in a 50-ton bioreactor based on comparative genomic analysis
Amphotericin, as an important macrolide antibiotic, is synthesized by Streptomyces nodosus . A high-yield S. nodosus ZJB2016050 was obtained by...
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Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering
BackgroundThe polyene macrocyclic compound amphotericin B (AmB) is an important antifungal antibiotic for the clinical treatment of invasive fungal...
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Amphiphilic copolymers modified with oleic acid and cholesterol by combining ring opening polymerization and click chemistry with improved amphotericin B loading capacity
Polymer micelles obtained from amphiphilic copolymers have emerged as promising drug vehicles given their nanometric size, simple release, and...
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An overview of opportunistic fungal infections associated with COVID-19
The COVID-19 survivors and long-term steroid administered patients exhibit a variety of fungal co-infections. The lives of COVID-19 patients and...
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Development of a yeast cell based method for efficient screening of high yield tacrolimus production strain
Tacrolimus (FK506) is a widely used and clinically important immunosuppressant drug that can be produced by fermentation of Streptomyces tsukubaensis ....
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Antifungals, Antimalarials, and Antivirals
This chapter includes a discussion of antifungal, antimalarial, and antiviral drugs. Similarities and differences of these with antibacterial...
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Synthesis, Antifungal Activity, and Molecular Docking Study of Some Novel Bistriazole Derivatives
AbstractIn this paper, 20 compounds containing bis-(1,2,3 and 1,2,4)-triazole structure were synthesized and their antifungal activities against Candi...
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Amphotericin B biosynthesis in Streptomyces nodosus: quantitative analysis of metabolism via LC–MS/MS based metabolomics for rational design
BackgroundAmphotericin B (AmB) is widely used against fungal infection and produced mainly by Streptomyces nodosus . Various intracellular...
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Human Fungal Infection, Immune Response, and Clinical Challenge—a Perspective During COVID-19 Pandemic
Fungi are a small but important part of the human microbiota and several fungi are familiar to the immune system, yet certain can cause infections in...
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Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives
Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein,...
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Synthesis and Antimicrobial Activity of Novel (1-Aryl-1H-1,2,3-triazol-4-yl)methyl 3-Acetamido-1-phenyl-1H-benzo[f]chromene-2-carboxylates
AbstractA series of novel (1-aryl-1 H -1,2,3-triazol-4-yl)methyl 3-acetamido-1-phenyl-1 H -benzo[ f ]chromene-2-carboxylates were synthesized from...
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Synthesis, antimalarial, antileishmanial evaluation, and molecular docking study of some 3-aryl-2-styryl substituted-4(3H)-quinazolinone derivatives
Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with promising antimalarial and antileishmanial activities. Herein,...
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Drug Delivery of Amphotericin B through Core-Shell Composite Based on PLGA/Ag/Fe3O4: In Vitro Test
This research aimed at develo** and designing a slow and targeted delivery of Amphotericin B (AmB) antibiotic by placing three types of shells...
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Anti-Candida sp. activity of Astronium urundeuva derivatives free and loaded into a nanostructured lipid system
Infections caused by Candida species increased, as well as species resistant to the most conventional antimicrobials. Thus, the search for new...
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Morphological aspects and the effectiveness of photodynamic inactivation against Rhizopus oryzae in different life cycles
Mucormycosis is an extremely aggressive fungal disease with a high mortality rate, especially in people with compromised immune systems. Most cases...
