Antifungals, Antimalarials, and Antivirals

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Chemistry of Antibiotics and Related Drugs
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Abstract

This chapter includes a discussion of antifungal, antimalarial, and antiviral drugs. Similarities and differences of these with antibacterial antibiotics are discussed. Drugs presented include amphotericin B, nystatin, azoles, allylamines, morpholines, fluoropyrimidines, DDT, quinine, chloroquine, pyrimethamine, artemisinin, proguanil, amantadine, acyclovir, lamivudine, zidovudine, and HIV protease and neuraminidase inhibitors. Mechanisms of action of the drugs and resistance development against them are discussed. PCR method for the detection of point mutations is also discussed.

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References

  1. Dutcher JD (1968) The discovery and development of amphotericin B. Dis Chest 54:40–42

    Google Scholar 

  2. Brajtburg J, Powderly WG, Kobayashi GS, Medoff G (1990) Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother 34:183–188

    Article  CAS  Google Scholar 

  3. Ellis D (2002) Amphotericin B: spectrum and resistance. J Antimicrob Chemother 49(S1):7–10

    Article  CAS  Google Scholar 

  4. Dismukes WE (2000) Introduction to fungal drugs. Clin Infect Dis 30:653–657

    Article  CAS  Google Scholar 

  5. Vanden Bossche H, Marichal P, Gorrens J, Coene MC, Willemsens G, Bellens D, Roels I, Moereels H, Janssen PA (1989) Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses 32(Suppl 1):35–52

    Article  Google Scholar 

  6. Lupetti A, Danesi R, Campa M, Tacca MD, Kelly S (2002) Molecular basis of resistance to azole antifungals. Trends Mol Med 8:76–81

    Article  CAS  Google Scholar 

  7. Ghannoum MA, Rice LB (1999) Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev 12:501–517

    Article  CAS  Google Scholar 

  8. Ferreira GF, Baltazar LM, Santos JRA, Monteiro AS, Fraga LAO, Resende-Stoianoff MA, Santos DA (2013) The role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii. J Antimicrob Chemother 68:1801–1811

    Article  CAS  Google Scholar 

  9. Mercer EI (1991) Morpholine antifungals and their mode of action. Biochem Soc Trans 19:788–793

    Article  CAS  Google Scholar 

  10. Vermes A, Guchelaar H-J, Dankert J (2000) Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother 46:171–179

    Article  CAS  Google Scholar 

  11. Waldorf AR, Polak A (1983) Mechanisms of action of 5-fluorocytosine. Antimicrob Agents Chemother 23:79–85

    Article  CAS  Google Scholar 

  12. Clancy CJ, Yu YC, Lewin A, Nguyen MH (1998) Inhibition of RNA synthesis as a therapeutic strategy against Aspergillus and Fusarium: demonstration of in vitro synergy between rifabutin and amphotericin B. Antimicrob Agents Chemother 42:509–513

    Article  CAS  Google Scholar 

  13. Coats JR (1990) Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides. Environ Health Perspect 87:255–262

    Article  CAS  Google Scholar 

  14. Rosenthal PJ (2008) Artesunate for the treatment of severe falciparum malaria. N Engl J Med 358:1829–1836

    Article  CAS  Google Scholar 

  15. Natarajan JK, Alumasa J, Yearick K, Ekoue-Kovi KA, Casabianca LB, de Dios AC, Wolf C, Roepe PD (2008) 4-N, 4-S & 4-O Chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs. chloroquine resistant malaria. J Med Chem 51:3466–3479

    Article  CAS  Google Scholar 

  16. Warhurst DC, Steele JCP, Adagu IS, Craig JC, Cullander C (2003) Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother 52:188–193

    Article  CAS  Google Scholar 

  17. Wellems TE, Plowe CV (2001) Chloroquine-resistant malaria. J Infect Dis 184:770–776

    Article  CAS  Google Scholar 

  18. Marks F, Evans J, Meyer CG, Browne EN, Flessner C, von Kalckreuth V, Eggelte TA, Horstmann RD, May J (2005) High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti region of Ghana. Antimicrob Agents Chemother 49:1101–1105

    Article  CAS  Google Scholar 

  19. Srivastava IK, Vaidya AB (1999) A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother 43:1334–1339

    Article  CAS  Google Scholar 

  20. Lisewski AM, Quiros JP, Ng CL, Adikesavan AK, Miura K, Putluri N, Eastman RT, Scanfeld D, Regenbogen SJ, Altenhofen L, Llinás M, Sreekumar A, Long C, Fidock DA, Lichtarge O (2014) Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by Artesunate. Cell 158:916–928

    Article  CAS  Google Scholar 

  21. Strommenger B, Kettlitz C, Werner G, Witte W (2003) Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus. J Clin Microbiol 41(9):4089–4094

    Article  CAS  Google Scholar 

  22. Bockelmann U, Dorries H-H, Ayuso-Gabella MN, de Marc MS, Tandoi V, Levantesi C, Masciopinto C, Van Houtte E, Szewzyk U, Wintgens T, Grohmann E (2009) Quantitative PCR monitoring of antibiotic resistance genes and bacterial pathogens in three European Artificial Groundwater Recharge Systems. Appl Environ Microbiol 75:154–163

    Article  Google Scholar 

  23. Newton CR, Graham A, Heptinstall LE, Powell SJ, Summers C, Kalshekerl N, Smith JC, Markham AF (1989) Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res 17:2503–2516

    Article  CAS  Google Scholar 

  24. Razonable RR (2011) Antiviral drugs for viruses other than human immunodeficiency virus. Mayo Clin Proc 86:1009–1026

    Article  CAS  Google Scholar 

  25. Kim KS, Sapienza VJ, Carp RI (1980) Antiviral activity of arildone on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother 18:276–280

    Article  CAS  Google Scholar 

  26. Wlodawer A, Vondrasek J (1998) Inhibitors of HIV-1 protease: a major success of structure assisted drug design. Annu Rev Biophys Biomol Struct 27:249–284

    Article  CAS  Google Scholar 

  27. Spurgers KB, Sharkey CM, Warfield KL, Bavari S (2008) Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses. Antiviral Res 78:26–36

    Article  CAS  Google Scholar 

  28. Strasfeld L, Chou S (2010) Antiviral drug resistance: mechanisms and clinical implications. Infect Dis Clin North Am 24:413–437

    Article  Google Scholar 

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Bhattacharjee, M.K. (2022). Antifungals, Antimalarials, and Antivirals. In: Chemistry of Antibiotics and Related Drugs. Springer, Cham. https://doi.org/10.1007/978-3-031-07582-7_8

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