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Comprehensive study on the inhibition mechanism of alpha-glucosidase by flavonoids via kinetic and structural analysis
Flavonoid consists of an extensive range of compounds with variable inhibitory activities against alpha-glucosidase, implicating its role in the...
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Metal Complexes of 1,2,4-Triazole Based Ligand: Synthesis, Structural Elucidation, DFT Calculations, Alpha-Amylase and Alpha-Glucosidase Inhibitory Activity Along with Molecular Docking Studies
In search of 1,2,4-triazole-based antidiabetic agents, new mixed-ligand chelates of the type, [M(L)(H 2 O) 3 ] (where M = Co(II), Ni(II), Cu(II) and...
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Probiotic Yogurt Supplemented with Lactococcus lactis R7 and Red Guava Extract: Bioaccessibility of Phenolic Compounds and Influence in Antioxidant Activity and Action of Alpha-amylase and Alpha-glucosidase Enzymes
The industry has increasingly explored the development of foods with functional properties, where supplementation with probiotics and bioactive...
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Effect of the Enzymatic Treatment of Phenolic-Rich Pigments from Purple Corn (Zea mays L.): Evaluation of Thermal Stability and Alpha-Glucosidase Inhibition
The impact of enzymatic treatment of Candida antarctica lipase B on a phenolics-rich extract from purple corn ( Zea mays L.) (PCE) was evaluated. PCE...
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α-Glucosidase Inhibition and Upregulation of PPARγ by Flavonoid Naringenin from Tinospora sinensis Stem, a Possible Mechanism of Antidiabetic Activity
Tinospora sinensis belonging to the family Menispermaceae distributed throughout India was used in the treatment of diabetes, piles, ulcerated...
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Synthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates
AbstractA new class of 3,3′-disubstituted chiral ( R )-BINOL-derived phosphoric acid derivatives has been prepared. The synthetic method has been...
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Proposed molecular mechanism of non-competitive inhibition using molecular dynamics simulations between α-glucosidase enzyme and mangostin compound as antidiabetic
ContextFurther understanding of the molecular mechanisms is necessary since it is important for designing new drugs. This study aimed to understand...
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Cassia siamea Role in Diabetes Management: Insights from In vitro and In silico Investigations on α-Glucosidase and α-Amylase Inhibition
Diabetes is a metabolic disorder which spread globally and it is expected that by 2030 diabetes prevalence will rise more than 300 million. The...
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The α-Amylase and α-Glucosidase Inhibition Capacity of Grape Pomace: A Review
The concept of functional foods is gaining more importance due to its role in maintaining a healthy status and preventing some metabolic diseases....
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Synthesis, antimicrobial and α-glucosidase inhibition of new benzimidazole-1,2,3-triazole-indoline derivatives: a combined experimental and computational venture
In the current research work, a new series of benzimidazole-1,2,3-triazole-indoline derivatives ( 5a–r ) were designed and synthesized by employing...
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Chemical composition, antioxidant, anticholinesterase, and alpha-glucosidase activity of Stevia rebaudiana Bertoni extracts cultivated in Algeria
Stevia rebaudiana Bertoni is an endemic species to Paraguay famous for its sweetening power and therapeutic potential for various diseases such as...
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Ligand-targeted fishing of α-glucosidase inhibitors from Tribulus terrestris L. based on chitosan-functionalized multi-walled carbon nanotubes with immobilized α-glucosidase
α-Glucosidase inhibitors in natural products are one of the promising drugs for the treatment of type 2 diabetes. However, due to the complexity of...
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In Vitro Inhibition of α-Amylase, α-Glucosidase and Antioxidant Activity of Milk Containing Fenugreek Seed Alcoholic Extract
The aim of this study was to evaluate the effect of fenugreek seed alcoholic extract (FSAE) at the levels of 0.15% and 0.30% (V/V) on the selected...
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Phytoconstituents from Urtica dioica (stinging nettle) of Sikkim Himalaya and their molecular docking interactions revealed their nutraceutical potential as α-amylase and α-glucosidase inhibitors
In this study, antioxidative methanolic leaf extract (MeOH-SIS) of Urtica dioica was characterized for anti-diabetic activity. The extract was...
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Synthesis of small size adamantane-linked aminothiazoles as potent inhibitors of urease, α-glucosidase and carbonic anhydrase and their molecular docking studies
The current study was aimed to synthesize a series of adamantane-linked aminothiazole derivatives ( 6a- ) and to assess their enzyme inhibitory...
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Novel polyhydroquinoline Schiff’s base derivatives: synthesis, characterization, in vitro α-glucosidase inhibitory, and molecular docking studies
Novel Schiff’s base hydrazone derivatives (1–24) based on polyhydroquinoline (PHQ) were synthesized in good to excellent yields via three step...
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A comparison of phenolic compounds, antioxidant activity, and α-glucosidase inhibitory activities of apple chips dried and fried by vacuum combined infrared radiation
In this study, the effects of different drying (180–325 W and 100–400 mmHg) and frying (250–350 W and 400 mmHg) parameters on phenolic compounds,...
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Insight into broad substrate specificity and synergistic contribution of a fungal α-glucosidase in Chinese Nong-flavor daqu
BackgroundChinese Nong-favor daqu, the presentative liquor starter of Baijiu, has been enriched with huge amounts of enzymes in degrading various...
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Physicochemical properties, in vitro starch digestibility, and enzyme inhibition of Irish potato-based functional flour as influenced by unripe plantain flour or sodium carboxymethylcellulose addition
The high glycemic index of Irish potato, as well as its suitability for indigenous food preparation may be improved through appropriate composite...
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Lignans With α-Glucosidase Inhibitory Activity from Codonopsis pilosula
The chemical constituents of Codonopsis pilosula (Franch.) Nannf. were isolated and purified by column chromatography. Two lignans were obtained from...
