Search
Search Results
-
Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells
Currently, gastric cancer is considered one of the major causes of high mortality and morbidity worldwide. Recent advances in therapeutics, clinical...
-
Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K/Akt/mTOR signaling pathway
BackgroundDespite being a promising strategy, current chemotherapy for gastric cancer (GC) is limited due to adverse side effects and poor survival...
-
Modulation of Autophagy in Gastric Cancer Cells and Sensitization to 5-Fluorouracil by Combination Therapy with Se–FA Nanoparticles
Recently, nanoparticle (NP)-based drugs have been developed to increase the efficiency of existing cancer treatment approaches; however, how NPs...
-
Integrating N-alkyl amide in the chalcone framework: synthesis and evaluation of its anti-proliferative potential against AGS cancer cell line
On the basis of the urgent need to develop innovative and safe anticancer compounds, a series of chalcones, functionalized with various substituents...
-
The Expression and Effect of ABCE1 in Gastric Adenocarcinoma
ATP-binding cassette E1 (ABCE1) is mainly related to the regulation of viral infection, cell multiplication, and anti-apoptosis. Previous reports...
-
Fabrication of Nickel/Zinc Oxide Nanocomposites from Citrus sinensis Extract Prompts Apoptosis Through Impeding JAK/STAT3 Signaling in Gastric Cancer
In this study, we sought to fabricate nickel/zinc oxide nanocomposites utilizing Citrus sinensis ( C. sinensis ) peel extract (CS-Ni/ZnO NCs) and...
-
PSMB2 knockdown suppressed proteasome activity and cell proliferation, promoted apoptosis, and blocked NRF1 activation in gastric cancer cells
Proteasome 20S Subunit Beta 2 (PSMB2) has been suggested to play several roles in cancer. However, the role of PSMB2 and its underlying mechanisms in...
-
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic...
-
The Interaction Between SMAD1 and YAP1 Is Correlated with Increased Resistance of Gastric Cancer Cells to Cisplatin
Drug resistance is a major obstacle leading to treating failure and poor outcome in gastric cancer (GC). This study explores the interaction between...
-
N6-Methyladenosine (m6A) Reader IGF2BP1 Accelerates Gastric Cancer Development and Immune Escape by Targeting PD-L1
N 6 -methyladenosine (m 6 A) functions as an important regulator in various human cancers, including gastric cancer. The immunotherapy targeting...
-
Baicalein facilitates gastric cancer cell apoptosis by triggering endoplasmic reticulum stress via repression of the PI3K/AKT pathway
ObjectiveGastric cancer (GC) remains a prevailing threat to life. Baicalein exhibits anti-cancer properties. This study estimated the mechanism of...
-
FGL1 Promotes Tumor Immune Escape in Stomach Adenocarcinoma via the Notch Signaling Pathway
Immune escape is the major reason for immunotherapy failure in stomach adenocarcinoma (STAD). We tried to reveal the underlying mechanism of FGL1...
-
WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1 Accelerates the Development of Gastric Cancer
AbstractThe long noncoding RNA FAM83H-antisense RNA 1 (FAM83H-AS1) is involved in gastric cancer (GC) development. This study determined whether...
-
LncRNA OIP5-AS1 Targets the miR-140-5p/UBR5 Cascade to Promote the Development of Gastric Cancer
Gastric cancer (GC) is a malignant tumor with the highest incidence among all kinds of malignant tumors in China. Long noncoding RNAs (LncRNAs) have...
-
Potential of Apoptosis-Inducing by a Novel Bio-synthesized CoFe2O4@Ag Nanocomposite in Gastric Cell Line at the Cellular and Molecular Level
Magnetic nanocomposites have gained great attention for their biomedical potentials. In this work, at first, CoFe 2 O 4 @Ag nanocomposite was...
-
Green Synthesis of a Novel PtFe2O4@Ag Nanocomposite: Implications for Cytotoxicity, Gene Expression and Anti-Cancer Studies in Gastric Cancer Cell Line
In recent years, many attempts have been made to find novel anticancer agents for the treatment of advanced and metastatic gastric cancers. Metal...
-
KAT2A Promotes the Succinylation of PKM2 to Inhibit its Activity and Accelerate Glycolysis of Gastric Cancer
Gastric cancer (GC) is one of the main causes of cancer-related death. Lysine acetyltransferases 2 A (KAT2A) is a succinyltransferase that plays an...
-
Cytotoxicity of Bio-Synthesized MgFe2O4@Ag Nanocomposite on Gastric Cancer Cell Line and Evaluation Its Effect on Bax, p53 and Bcl-2 Genes Expression
Gastric cancer is a major human health threat and finding novel and effective anticancer compounds against it is crucially important. Silver...
-
Effects of a Potential Probiotic Strain Lactobacillus gasseri ATCC 33323 on Helicobacter pylori-Induced Inflammatory Response and Gene Expression in Coinfected Gastric Epithelial Cells
In the present study, we aimed to investigate the modulatory effects of a potential probiotic bacterium Lactobacillus gasseri ATCC 33323 on Helicobacte...
-
Anticancer Effect of Enterocin A-Colicin E1 Fusion Peptide on the Gastric Cancer Cell
Cancer is one of the most causes of death all over the world, although improvements in its treatment and recognition. Due to the limitations of...