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Performance comparison between solid phase extraction and magnetic carbon nanotubes facilitated dispersive-micro solid phase extractions (Mag-CNTs/d-µSPE) of a cyanide metabolite in biological samples using GC–MS
Dispersive-micro solid phase extraction (d-µSPE) has gained increasing attention due to its convenience, effectiveness, and flexibility for sorbent...
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Cyclic Isothiourea in Drug Design
The present minireview concerns the application of cyclic isothiourea moiety (with endocyclic sulfur atom) in drug design and includes the examples...
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Methyl Trifluoropyruvate Pyrazin-2-ylimine in Cyclocondensation and Cycloaddition Reactions
The transformations of methyl trifluoropyruvate pyrazin-2-ylimine in the cyclocondensation reactions with 2-aminothiazoline, amidines,...
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Methyl esters of 2-aminotetrahydrobenzothiophene-3-carboxylic acids decorated with trifluoromethyl-containing heterocycles
Methyl 2-aminothiophene-3-carboxylates were modified with trifluoromethyl-containing five-membered heterocycles by cyclocondensation of methyl...
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Synthesis of new N-(pyridin-3-ylmethyl)-2-aminothiazoline derivatives possessing anticholinesterase and antiradical activity as potential multifunctional agents for the treatment of neurodegenerative diseases
New N -(pyridin-3-ylmethyl)-2-aminothiazolines containing various substituents at the 5 position of the thiazoline ring and the 4- tert -butylbenzyl,...
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Concurrent determination of cyanide and thiocyanate in human and swine antemortem and postmortem blood by high-performance liquid chromatography–tandem mass spectrometry
Cyanide (in the form of cyanide anion (CN − ) or hydrogen cyanide (HCN), inclusively represented as CN) can be a rapidly acting and deadly poison, but...
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Recent molecularly imprinted polymers applications in bioanalysis
Molecular imprinted polymers (MIPs) as extraordinary compounds with unique features have presented a wide range of applications and benefits to...
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Molecularly imprinted polymers as a selective sorbent for forensic applications in biological samples—a review
Molecularly imprinted polymers (MIP) consist of a molecular recognition technology with applicability in different areas, including forensic...
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Simultaneous determination of urinary 31 metabolites of VOCs, 8-hydroxy-2′-deoxyguanosine, and trans-3′-hydroxycotinine by UPLC-MS/MS: 13C- and 15N-labeled isotoped internal standards are more effective on reduction of matrix effect
Human beings are inevitably exposed to volatile organic compounds (VOCs) of anthropogenic emissions as they are ubiquitous atmospheric pollutants....
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Modification of biologically active amides and amines with fluorine-containing heterocycles 12.* Endo- and exocyclic modifications of the drug riluzole with trifluoromethyl-containing heterocycles
New derivatives of the drug riluzole, 6-(trifluoromethoxy)benzothiazol-2-ylamine, modified at the endo- and exocyclic nitrogen atoms with...
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Structural and functional insight into human O-GlcNAcase
O-GlcNAc hydrolase (OGA) removes O -linked N -acetylglucosamine ( O -GlcNAc) from a myriad of nucleocytoplasmic proteins. Through co-expression and...
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Molecular design of N,N-disubstituted 2-aminothiazolines as selective carboxylesterase inhibitors
Selective carboxylesterase inhibitors are employed as modulators of hydrolytic metabolism of ester or amide-containing drugs. Using the Molecular...
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The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a very serious public health problem. Currently, there is no effective treatment for AD. Among the many biochemical...
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Cyclocondensation of methyl 2-(5-methylisoxazol-3-yl)imino-3,3,3-trifluoropropionate with 1,3-binucleophiles
Cyclocondensation of methyl 2-(5-methylisoxazol-3-yl)imino-3,3,3-trifluoropropionate with 1,3-binucleophiles such as benzamidines, aminothiazoline,...
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Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds
Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers’ Urine (Frozen) and SRM 3673 Organic Contaminants in...
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Methyl trifluoropyruvate N-(pyrimidin-2-yl)imines in cyclocondensation reactions with 1,3-binucleophilic reagents
Cyclocondensation reactions of methyl trifluoropyruvate N -(pyrimidin-2-yl)imines with N -substituted ureas, N -benzylbenzamidine, 2-aminothiazoline,...
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Methyl 3,3,3-trifluoro-2-(thiazol-2-ylimino)propionate in cycloaddition and cyclocondensation reactions
The behavior of methyl 3,3,3-trifluoro-2-(thiazol-2-ylimino)propionate ( 1 ) in cycloaddition and cyclocondensation reactions was studied....
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Develo** inhibitors of glycan processing enzymes as tools for enabling glycobiology
Glycoconjugates are ubiquitous biomolecules found in all kingdoms of life. These diverse structures are metabolically responsive and occur in a cell...
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Modification of biologically active amides and amines with fluorine-containing heterocycles 4. Trifluoromethyl-containing heterocyclic pyracetam derivatives
A one-pot method for the synthesis of trifluoromethyl-containing heterocyclic pyracetam derivatives has been suggested by the reaction of pyracetam,...