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Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors
BackgroundGene therapy remains a significant challenge due to lots of barriers limiting the genetic manipulation technologies. As for non-viral...
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Development of targeted therapy therapeutics to sensitize triple-negative breast cancer chemosensitivity utilizing bacteriophage phi29 derived packaging RNA
BackgroundTo date, triple-negative breast cancer (TNBC) treatment options are limited because of the loss of target receptors and, as a result, are...
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Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers
Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the...
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A milk-based self-assemble rotavirus VP6–ferritin nanoparticle vaccine elicited protection against the viral infection
BackgroundRotavirus is the leading cause of severe dehydrating diarrhea in young children and the inner capsid protein VP6 is a potential vaccine...
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Carbon nanotubes in electrochemical, colorimetric, and fluorimetric immunosensors and immunoassays: a review
This review (with 126 references) summarizes the progress that has been made in the use of carbon nanotubes (CNTs) in immunoassays and immunosensors....
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Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged...
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Recent Advances in Synthetic Biology for the Engineering of Lactic Acid Bacteria
Lactic acid bacteria (LAB) have a long historical record of usage in many types of food-related bioprocesses, and as LAB have been found to have...
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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual...
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Detecting Protein–Glycolipid Interactions Using CaR-ESI-MS and Model Membranes: Comparison of Pre-loaded and Passively Loaded Picodiscs
Catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS), implemented using model membranes (MMs), is a promising approach for the...
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Targeted LC-ESI-MS2 characterization of human milk oligosaccharide diversity at 6 to 16 weeks post-partum reveals clear staging effects and distinctive milk groups
Many molecular components in human milk (HM), such as human milk oligosaccharides (HMOs), assist in the healthy development of infants. It has been...
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Assessment of Carrot Callus as Biofactories of an Atherosclerosis Oral Vaccine Prototype
Atherosclerosis is a pathology leading to cardiovascular diseases with high epidemiologic impact; thus, new therapies are required to fight this...
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Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context
The objective of this critical review is to provide an overview of how emerging bioanalytical techniques are expanding our understanding of the...
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Collision-Induced Unfolding Is Sensitive to the Polarity of Proteins and Protein Complexes
Collision-induced unfolding (CIU) uses ion mobility to probe the structures of ions of proteins and noncovalent complexes as a function of the extent...
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Nanomaterial enabled sensors for environmental contaminants
The need and desire to understand the environment, especially the quality of one’s local water and air, has continued to expand with the emergence of...
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TiO2 Nanomaterials in Photoelectrochemical and Electrochemiluminescent Biosensing
Titanium dioxide (TiO 2 ) is increasingly being used in biosensing applications. Herein, we review the most recent developments in photoelectrochemical...
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Penicillium Family as Emerging Nanofactory for Biosynthesis of Green Nanomaterials: A Journey into the World of Microorganisms
Synthesis of biometal nanoparticles (BM-NPs) in a green-synthetic approach is the favorite research in the scope nanobiotechnology. Based on the...
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TiO2 Nanomaterials in Photoelectrochemical and Electrochemiluminescent Biosensing
Titanium dioxide ( TiO2) is increasingly being used in biosensing applications. Herein, we review the most recent developments in...
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Extracellular phosphorylation drives the formation of neuronal circuitry
Until recently, the existence of extracellular kinase activity was questioned. Many proteins of the central nervous system are targeted, but it...
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Comparative immunogenicity of preparations of yeast-derived dengue oral vaccine candidate
BackgroundDengue is listed as a neglected tropical disease by the Center for Disease Control and Preservation, as there are insufficient integrated...
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Pathogen Immunoassay in Food
Immunoassays such as enzyme-linked immunosorbent assays (ELISA) and immunochromatographic strip assays have been widely developed for pathogen...