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Chemical profiling, phytotoxicity, cytotoxicity, and antibacterial activity of the essential oil of a high-altitude plant, Allardia tridactylites, from the Trans-Himalayan Region, Ladakh
The era of ongoing research is clearly progressing in the direction of chemical profiling and the evaluation of pharmacological and toxicological...
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Medicinal Plants in Controlling and Treatment of Diseases Caused by Viral Hemorrhagic Septicemia Virus (VHSV)
Numerous wild fish species around the world are affected by the viral hemorrhagic septicemia virus (VHSV), which is extremely contagious and...
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Influence of prefoldin subunit 4 on the tolerance of Kluyveromyces marxianus to lignocellulosic biomass-derived inhibitors
BackgroundKluyveromyces marxianus is a potentially excellent host for microbial cell factories using lignocellulosic biomass, due to its...
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Anticancer Activity of New Organotin Complexes with Heterocyclic Thioamides
AbstractNew complexes I – IV of di- tert -butyltin with ligands based on heterocyclic thioamides (2-mercaptobenzoxazole, 2-mercaptobenzothiazole,...
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Nonmonotone invasion landscape by noise-aware control of metastasis activator levels
A major pharmacological assumption is that lowering disease-promoting protein levels is generally beneficial. For example, inhibiting metastasis...
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Cell cycle inhibition, apoptosis, and molecular docking studies of the novel anticancer bioactive 1,2,4-triazole derivatives
Several 3-alkylsulfanyl-1,2,4-triazole derivatives were synthesized and their relevant structures confirmed based on their elemental analysis and...
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Plant Secondary Metabolites for Defense Against Herbivores
In the era of sustainable development, the current focus is on the development of the new tools to control the pest infestation on different crops...
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Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury
Spinal cord injury (SCI) is accompanied by loss of Zn 2+ , which is an important cause of glutamate excitotoxicity and death of local neurons as well...
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Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Drugs that target histone deacetylase (HDAC) entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target...
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Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN
Tyrosine kinase inhibitors have been the standard treatment for patients with Philadelphia chromosome-positive (Ph + ) leukemia. However, a series of...
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The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro
Potential role and associated mechanisms of Annexin A8 (ANXA8), a member of the Annexins family, in cervical squamous cell carcinoma (CESC) are still...
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A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy
Combretastatin A4 phosphate (CA4P) is a potent vascular disrupting agent with good water solubility. However, it is only effective at high doses,...
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Optogenetic control of cofilin and αTAT in living cells using Z-lock
Here we introduce Z-lock, an optogenetic approach for reversible, light-controlled steric inhibition of protein active sites. The light oxygen...
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Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1...
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Current Developments of Pyrrolo[2,3-d]pyrimidines with Anticancer Potential (A Review)
AbstractAnticancer chemotherapeutics are effective weapons for cancer therapy, but the continuous emergency of multidrug-resistant cancer and the...
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Cyanobacteria as a Biocontrol Agent
Cyanobacteria, one of the least investigated microbes, may synthesize and generate a significant number of antimicribial secondary metabolites. As...
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Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase...
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Identification and Optimization of Protein Tyrosine Phosphatase Inhibitors Via Fragment Ligation
Phosphotyrosine biomimetics are starting points for potent inhibitors of protein tyrosine phosphatases (PTPs) and, thus, crucial for drug...
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New Benzoazepine Alkaloids of Colchicum speciosum
The object of this research was isolation of the two new benzoazepine alkaloids –...
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Anticancer Potential of Nature-Derived Isoquinoline Alkaloids (A Review)
AbstractIsoquinoline alkaloids, vastly found in nature and predominant in Papaveraceae , Berberidaceae , and Ranunculaceae plant families, possess...