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Immunogenicity Monitoring Cell Chip Incorporating Finger-Actuated Microfluidic and Colorimetric Paper-Based Analytical Functions
Recently, with the development of microfluidic chips, attempts to integrate cell culture and biomedical material testing functions into a single chip...
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Two New Antibacterial Anthraquinones from Cultures of an Endophytic Fungus Phomopsis sp.
Two new anthraquinones, 3-hydroxy-6-hydroxymethyl-2,5-dimethylanthraquinone (1) and 6-hydroxymethyl-3-methoxy-2,5-dimethylanthraquinone (2), were...
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Biomarkers of Systemic Inflammation in Local and Diffuse Peritonitis
AbstractThe progression of purulent inflammation in any acute surgical abdominal pathology can lead to local or diffuse peritonitis. The parameters...
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Red ginseng extract regulates differentiation of monocytes to macrophage and inflammatory signalings in human monocytes
This study was aimed to investigate the effect of red ginseng extract (RGE) on monocyte to macrophage differentiation and inflammatory signalings in...
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M2 macrophage-derived extracellular vesicles augment immune evasion and development of colorectal cancer via a circRNA_CCDC66/microRNA-342-3p/metadherin axis
The M2 macrophages are major components in the tumor microenvironment and are closely linked to immune suppression and tumor metastasis. This work...
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SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma Cells by Upregulating EVI2A
Although gemcitabine (GEM) is the first‑line drug for advanced pancreatic adenocarcinoma (PAAD), the development of GEM resistance severely limits...
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The Therapeutic Potential of 4-Methoxy-1-methyl-2-oxopyridine-3-carbamide (MMOXC) Derived from Ricinine on Macrophage Cell Lines Infected with Methicillin-Resistant Strains of Staphylococcus aureus
The incidences of methicillin-resistant strains of Staphylococcus aureus (MRSA) and their survival inside the macrophages are the major attributes of...
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A benzothiazole-based fluorescence probe for imaging of peroxynitrite during ferroptosis and diagnosis of tumor tissues
Ferroptosis, as a new regulated mode of cell death, is mainly characterized by iron-dependent accumulation of lipid peroxides related to reactive...
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Standardized Workflow for Mass-Spectrometry-Based Single-Cell Proteomics Data Processing and Analysis Using the scp Package
Mass-spectrometry (MS)-based single-cell proteomics (SCP) explores cellular heterogeneity by focusing on the functional effectors of the...
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Particle Assays
Many unique advantages make SPRi valuable not only for the studies of biomolecules such as proteinProtein(s), DNA and RNA, carbohydrates and their...
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Green Extraction Technologies and Kombucha Elaboration Using Strawberry Tree (Arbutus unedo) Fruits to Obtain Antioxidant and Anti-Inflammatory Fractions
The fruits of Arbutus unedo (strawberry tree, ST) have been widely used for culinary and medicinal purposes because of their content in phenolic...
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Holy Thistle
The medicinal plant Silybum marianum has long been utilised as a hepatoprotective treatment. It has been used to treat a variety of liver conditions...
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The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg
BackgroundPostmenopausal osteoporosis (PMO) is a chronic condition characterized by decreased bone strength. This study aims to investigate the...
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Structural, Theoretical Investigations, Hirshfeld Surface Analysis, and Cytotoxicity Profile of a Neocuproine-Co(II)-Based Discrete Homodinuclear Complex
In this work, we aimed to synthesize a new cobalt(II) complex, namely [Co 2 (μ-HIPA)(NC) 2 (H 2 O) 3 (NO 3 )]·(NO 3 )(C 2 H 5 OH)( 1 ) (where H 3 IPA = 5-hydroxy...
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Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model
Interleukin (IL)-21 is a major lineage-defining factor that promotes Tfh cell differentiation. The current study investigated the molecular basis of...
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Development of a human phage display-derived anti-PD-1 scFv antibody: an attractive tool for immune checkpoint therapy
BackgroundThe PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies...
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Luteolin Mitigates Diabetic Dyslipidemia in Rats by Modulating ACAT-2, PPARα, SREBP-2 Proteins, and Oxidative Stress
Diabetic dyslipidemia is a crucial link between type-2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular diseases (ASCVD). Natural...
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Induction of therapeutic immunity and cancer eradication through biofunctionalized liposome-like nanovesicles derived from irradiated-cancer cells
Immunotherapy has revolutionized the treatment of cancer. However, its efficacy remains to be optimized. There are at least two major challenges in...
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Isorhamnetin: Current knowledge and potential benefits for disease management
Isorhamnetin is a flavonol that naturally occurs in a variety of plants and is also present in several plant-derived foodstuffs and beverages,...
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A lysosome-targetable fluorescent probe based on HClO-mediated cyclization reaction for imaging of hypochlorous acid
Misplaced or excessive hypochlorous acid in lysosomes has a close association with lots of diseases, so monitoring hypochlorous acid in lysosomes is...
