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Biobased Nanomaterials in Drug Delivery
Biobased nanomaterials have emerged as a pivotal element in modern drug delivery, garnering substantial attention within scientific research. These...
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Artificial Intelligence in Vaccine and Drug Design
Knowledge in the fields of biochemistry, structural biology, immunological principles, microbiology, and genomics has all increased dramatically in...
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Hit diffusion: limitations to drug discovery and structure-based design
Modern drug discovery employs a ‘screening funnel’ to pick compounds worthy of advancing to the clinic, a multi-step process linking a series of...
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Individual and collective human intelligence in drug design: evaluating the search strategy
In recent years, individual and collective human intelligence, defined as the knowledge, skills, reasoning and intuition of individuals and groups,...
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Nanofluidic Technologies for Drug Screening and Drug Delivery
Recently, nanofluidics exploiting 10–1000 nm spaces has developed and suggested a potential of novel analytical methods for pharmaceutical studies...
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Drug Delivery Systems for Cartilage
A dense network of extracellular matrix and lack of vascularization pose a major challenge in the delivery of therapeutics in the cartilage. Recent...
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Drug Delivery Systems and Cardiovascular Disease
Clinically, with the treatment of cardiovascular disease in addition to surgery and interventional therapy, drug therapy is also a common means. With...
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Structure-based drug design and molecular dynamics studies of an allosteric modulator targeting the protein–protein interaction site of PDK1
ContextProtein–protein interaction interfaces play a major role in cell signaling pathways. There is always a great interest in develo**...
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Biological Methods for Drug Delivery
Drug delivery systems (DDS) are widely employed to enhance the bioavailability of a drug while alleviating its potential toxicity. Biomedical...
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An outlook on suicide enzyme inhibition and drug design
There have been recent renewed interests in the importance of suicide enzyme inhibition. The principal objective of this review is to investigate all...
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Manufacturing the Biopharmaceutical Drug Product
Manufacture of the finished drug product is the last process step (from starting materials to drug substance and now to drug product) for the...
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FMO Drug Design Consortium
Drug discovery is one of the most important applications of the fragment molecular orbital (FMO) method. By using the FMO calculation, it is possible...
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Current Trends in Computational Modeling for Drug Discovery
This contributed volume offers a comprehensive discussion on how to design and discover pharmaceuticals using computational modeling techniques. The...
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Starch-Based Hydrogel in Drug Delivery Applications
Polymer-based hydrogels, existing in a three-dimensional form, are water-insoluble that have the characteristic features of absorbing and retaining a...
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Alginate Based Carriers for Topical Drug Delivery
Topical drug delivery is a promising approach for drug susceptible to degradation on oral administration or drug undergoing first pass effect....
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Drug Delivery Systems for Bone
Repair and regeneration of large or compromised bone defects is a significant clinical challenge. Autologous bone-grafting procedures offer a partial...
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Lithography in Drug Delivery
Research on advanced formulations and manufacturing methods to create multifunctional drug delivery systems has been actively pursued to optimize...
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PermuteDDS: a permutable feature fusion network for drug-drug synergy prediction
MotivationDrug combination therapies have shown promise in clinical cancer treatments. However, it is hard to experimentally identify all drug...
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Molecular chameleons in drug discovery
Molecular chameleons possess a flexibility that allows them to dynamically shield or expose polar functionalities in response to the properties of...
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Design, Synthesis, Drug-Likeness and In Silico Prediction of Polycyclic Aromatic Schiff base Tethered Organosilatranes
The present article includes the generation of aromatic Schiff base tethered organosilatranes via two step synthetic pathways starting from...