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Interactions Between Amyloid-β (1-42) and Hydroxyapatite-Cholesterol Spherules Associated with Age-Related Macular Degeneration
Drusen deposition on sub-retinal pigment epithelium is the causal factor for age-related macular degeneration for the old-aged individuals. These...
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Supported Lipid Bilayers (SLBs) to Study Amyloid-Lipid Membrane Interactions with Atomic Force Microscopy
Supported lipid bilayers (SLBs) are model membrane systems that can be used to study the interaction between amyloid fibers and membranes with atomic...
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Preparation of Amyloid Fibrils Using Recombinant Technology
Amyloid fibrils are widely investigated as they are directly associated with various neurodegenerative diseases. For example, a vast of experimental...
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Dual-mode transfer response based on electrochemical and fluorescence signals for the detection of amyloid-beta oligomers (AβO)
An aptamer sensor has been developed utilizing a dual-mode and stimuli-responsive strategy for quantitative detection of AβO (amyloid-beta...
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Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition
BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for...
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Plasmonics Optoelectronics Nanobiosensors for Detection of Alzheimer’s Disease Biomarker via Amyloid-Beta (Aβ) in Near-Infrared
The development of diagnostic factors for such neurodegenerative disorders as Alzheimer’s disease is hindered by several limitations that are often...
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Supramolecule self-assembly synthesis of amyloid phenylalanine-Cu fibrils with laccase-like activity and their application for dopamine determination
Laccases are multicopper proteins for dioxygen-involved oxidation of a broad spectrum of organic compounds. I Novel amyloid-like phenylalanine-Cu...
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Competitive fluorescent immunoassay for the ultrasensitive determination of amyloid beta peptide1-42 based on Ag@SiO2@N, S-GQD nanocomposites
AbstractA competitive fluorescent immunoassay is described for the ultrasensitive determination of amyloid beta peptide1-42 (Aβ1-42), a biomarker for...
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Direct, Rapid, and Simple Evaluation of the Expression and Conformation of Beta-Amyloid in Bacterial Cells by FTIR Spectroscopy
The expression and conformation of bacterial proteins and peptides can be monitored in situ by Fourier transform infrared spectroscopy (FTIR),...
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Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease
Amyloid aggregation, which disrupts protein homeostasis, is a common pathological event occurring in human neurodegenerative diseases (NDs). Numerous...
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Structural Information on Bacterial Amyloid and Amyloid-DNA Complex Obtained by Small-Angle Neutron or X-Ray Scattering
Small-angle scattering is a powerful technique to obtain structural information on biomacromolecules in aqueous solution at the sub-nanometer and...
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Evaluation of the Role of Bacterial Amyloid on Nucleoid Structure Using Cryo-Soft X-Ray Tomography
Bacterial chromosomal DNA is packed within a non-membranous structure, the nucleoid, thanks to nucleoid associated proteins (NAPs). The role of...
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Analysis of Bacterial Amyloid Interaction with Lipidic Membrane by Orientated Circular Dichroism and Infrared Spectroscopies
Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), and orientated circular dichroism (OCD) are complementary spectroscopies...
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O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous...
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Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β
The progression of neurodegenerative disorders can lead to impaired neurotransmission; however, the role of pathogenic factors associated with these...
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Destabilization of the Alzheimer’s amyloid-β peptide by a proline-rich β-sheet breaker peptide: a molecular dynamics simulation study
The amyloid-β peptide exists in the form of fibrils in the plaques found in the brains of patients with Alzheimer’s disease. One of the therapeutic...
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Interactions between copper (II) and β-amyloid peptide using capillary electrophoresis–ICP–MS: Kd measurements at the nanogram scale
Although the interaction between the β-amyloid peptide and copper (II) appears to play an important role in Alzheimer’s disease, the affinity...
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Fluorescent aptasensor based on conformational switch–induced hybridization for facile detection of β-amyloid oligomers
Aβ oligomers (AβO) are a dominant biomarker for early Alzheimer’s disease diagnosis. A fluorescent aptasensor coupled with conformational...
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Colorimetric cellulose-based test-strip for rapid detection of amyloid β-42
An innovative sensing assay is described for point-of-care (PoC) quantification of a biomarker of Alzheimer’s disease, amyloid β-42 (Aβ-42). This...
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Fluorescence Resonance Energy Transfer (FRET)-Based ThT Free Sensing of Beta-Amyloid Fibrillation by Carbon Dot-Ag Composites
Amyloid-beta proteins that form cytotoxic aggregates called amyloid-β derived diffusible ligands are responsible for various neurodegenerative...
