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Molecular Mechanisms of β-Adrenergic Receptor Desensitization
Desensitization or adaptation is well known in biological regulation. Also referred to as tachyphylaxis, tolerance or refractoriness, it is most...
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Regulation of Neuronal Adenylate Cyclase
Receptors for a panoply of neurotransmitters and neuromodulators are known to couple to the adenylate cyclase system. In the past few years we have...
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On the Economics of Binding Energies
There is a widespread impression that the best, most specific small molecules that make things happen in biological processes are the molecules that...
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Thyroid Membrane Nad-Glycohydrolase and Adp•Ribosyl-Transferase, Possibly Relevant to TSH Action
Cholera toxin stimulates the adenylate cyclase complex by mono-ADPribosylating the guanine regulatory component (N-protein) [1]. Although cholera...
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Synaptosomes and Synaptic Membranes: Isolation and Morphology
The isolation of synaptosomes by conventional sucrose densitygradient procedures [l, 2] requires several hours. Several more hours are needed to...
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Architecture of Plasma Membrane Hormone Receptor-Effector Systems
The hormonally responsive adenylate cyclase system is an example of a system subject to complex regulation that undergoes shifts in equilibria of...
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Hormone Receptor — Adenylate Cyclase Interaction: Superpotency, Superaffinity and Desensitization Phenomena
(1) Cell fusion studies have shown that β-adrenergic receptors concerned in adenylate cyclase (AC) activation can move from one cell to another. (2)...
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Pathophysiology of the Enterotoxic and Viral Diarrheas
As amply documented in other papers in this volume, there is no doubt that diarrheal diseases are the world’s biggest health problem. They constitute...
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Interactions of Diarrhea and Malnutrition
The diarrheal diseases are a major cause of death in all poor societies. Typically, these populations have a youthful age structure, with nearly half...
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Photoactivated Hydrophobic Reagents for Integral Membrane Proteins
Photoactivated hydrophobic reagents are being developed to label those regions of integral membrane proteins that lie within the hydrocarbon core of...
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Some Observations that May Pertain to Structure-Function Relationships of hCGβ
Atassi (1977) in a series of elegant experiments defined the three antigenic determinants on the disulfide-containing protein lysozyme. They are all...
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Biosynthesis of Mitochondrial Membrane Proteins
Current interest in membrane biogenesis is focused on a series of questions that pertain to: the structure and regulation of genes for membrane...
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Roles of Vitamins as Coenzymes
Vitamins that serve as precursors of coenzymes are principally the B vitamins. These substances occur not only in the free form but also in bound...