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A Ti/Nb-functionalized COF material based on IMAC strategy for efficient separation of phosphopeptides and phosphorylated exosomes
In this work, on the basis of an immobilized metal ion affinity chromatography enrichment strategy, a new kind of covalent organic framework (COF)...
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Construction of metal–organic framework-based multienzyme system for l-tert-leucine production
Chiral compounds are important drug intermediates that play a critical role in human life. Herein, we report a facile method to prepare multi-enzyme...
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Label-free detection of biomolecules using inductively coupled plasma mass spectrometry (ICP-MS)
Bioassays using inductively coupled plasma mass spectrometry (ICP-MS) have gained increasing attention because of the high sensitivity of ICP-MS and...
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Bio-Specific Extraction/Receptor Fishing for Screening of Active Components in Chinese Medicines
In this chapter, the principles and processes of bio-specific extraction/receptor fishing, such as equilibrium dialysis, centrifugation, and...
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Chromatographic Separation with On-Line (Bio)Assay, a Rapid Technique for Screening Active Compounds from Chinese Medicines
Due to the complex compositions of Chinese medicine (CM), how to rapidly and efficiently discovery the biologically active components from them is a...
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Exploring new targets and chemical space with affinity selection-mass spectrometry
Affinity selection-mass spectrometry (AS-MS) is a high-throughput screening (HTS) technique for drug discovery that enables rapid screening of large...
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On the Use of Diazonium Salts in the Design of Catalytic Hybrid Materials and Coatings
We summarize the existing knowledge on the use of diazonium salts as a new generation of surface modifier and coupling agents to functionalize...
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Hybrid Organic-Inorganic Materials Based on Organophosphorus Derivatives
Because P-O-Metal and P-C linkages are quite stable, organophosphorus derivatives offer a general alternative to silicon-based coupling in the field...
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Co-immobilization of electron mediator and laccase onto dialdehyde starch cross-linked magnetic chitosan nanomaterials for organic pollutants’ removal
In this study, an amino-functionalized ionic liquid-modified magnetic chitosan (MACS-NIL) containing 2,2-diamine-di-3-ethylbenzothiazolin-6-sulfonic...
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Dual metal cations coated magnetic mesoporous silica probe for highly selective capture of endogenous phosphopeptides in biological samples
For the first time, dual metal ions (Ti 4+ -Zr 4+ ) were successfully modified into the channel of magnetic mesoporous silica to obtain an affinity probe...
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Aptamer-Based Affinity Chromatography for Protein Extraction and Purification
Aptamers are oligonucleotide molecules able to recognize very specifically proteins. Among the possible applications, aptamers have been used for...
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Recent Advances in CNT-based FET Transistor Biosensors to Detect Biomarkers of Clinical Significance
The development of advanced materials has attracted interest for promising novel applications in biosensing and realm of nanophotonics. This interest...
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Electrochemical enzyme-based blood uric acid biosensor: new insight into the enzyme immobilization on the surface of electrode via poly-histidine tag
In a new approach, we considered the special affinity between Ni and poly-histidine tags of recombinant urate oxidase to utilize Ni-MOF for...
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Co-immobilized Alcohol Dehydrogenase and Glucose Dehydrogenase with Resin Extraction for Continuous Production of Chiral Diaryl Alcohol
Ni 2+ -functionalized porous ceramic/agarose composite beads (Ni-NTA Cerose) can be used as carrier materials to immobilize enzymes harboring a metal...
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Aptamer Molecular Evolution for Liquid Biopsy
Liquid biopsy can provide comprehensive and real-time physiological and pathological information in a noninvasive and longitudinal monitoring manner,...
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Aptamer Molecular Evolution for Liquid Biopsy
Liquid biopsy can provide comprehensive and real-time physiological and pathological information in a noninvasive and longitudinal monitoring manner,...
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Preparation of a highly selective Mo(VI) optical sensor by immobilization of quercetin on a transparent agarose membrane
Development of a highly selective optical sensor for determining Mo(VI) in water samples has been reported. The optical sensor was prepared through...
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Immobilization study of a monomeric oleate hydratase from Rhodococcus erythropolis
The chemical, pharmaceutical, and cosmetic industries are currently confronted with the challenge of transitioning from traditional chemical...
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Zinc Imidazolate Metal–Organic Frameworks-8-Encapsulated Enzymes/Nanoenzymes for Biocatalytic and Biomedical Applications
The pervasive nature, efficiency, and selectivity as catalysts make enzymes indispensable in chemical syntheses and drug delivery. Enzyme’s use is...
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Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens
It is essential to develop ultrasensitive biosensors for cancer detection and treatment monitoring. In the development of sensing platforms,...
