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Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)
An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism. Hepatic fibrosis is characterized...
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Potential interplay between tumor size and vitamin D receptor (VDR) polymorphisms in breast cancer prognosis: a prospective cohort study
PurposeVitamin D has some anticancer properties that may decrease breast cancer risk and improve prognosis. The aim was to investigate associations...
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Role of Neural Stem Cells and Vitamin D Receptor (VDR)–Mediated Cellular Signaling in the Mitigation of Neurological Diseases
Specific stem cell–based therapies for treating Alzheimer’s disease, Parkinson’s disease, and schizophrenia are gaining importance in recent years....
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Vitamin D receptor rs3782905 and vitamin D binding protein rs7041 polymorphisms are associated with hepatocellular carcinoma susceptibility in cirrhotic HCV patients
BackgroundThe severity of chronic hepatitis C and susceptibility to hepatocellular carcinoma (HCC) are associated with genetic variations within...
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The role of vitamin D receptor in predentin mineralization and dental repair after injury
Dentin is a permeable and complex tubular composite formed by the mineralization of predentin that mineralization and repair are of considerable...
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Biochemical markers and FokI and TaqI vitamin D receptor genes polymorphism in rheumatoid arthritis
BackgroundPrevious studies have reported the role of genes in different metabolic processes in the human body, and any variation in gene...
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Vitamin D receptor gene polymorphism and polycystic ovary syndrome susceptibility
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. This study was designed to investigate the associations of...
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Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis
Tight junctions are essential for barrier integrity, inflammation, and cancer. Vitamin D and the vitamin D receptor (VDR) play important roles in...
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Vitamin D receptor gene polymorphisms are associated with the risk and features of myasthenia gravis in the Han Chinese population
Vitamin D receptor gene (VDR) polymorphisms are candidate genetic variants for susceptibility to autoimmune diseases. Here, we explored the...
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Vitamin D receptor prevents tumour development by regulating the Wnt/β-catenin signalling pathway in human colorectal cancer
BackgroundColorectal cancer (CRC) is a common disease threatening human lives worldwide, and vitamin D receptor (VDR) contributes protective roles in...
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Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is...
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Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor
Several studies have shown an association between some variants in the vitamin D receptor ( VDR ) and the GC vitamin D binding protein ( GC ) genes with...
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Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
BackgroundVitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies....
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Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes
Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D...
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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy
Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose...
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Vitamin D Receptor (VDR) Gene Polymorphisms and Risk of Coronary Artery Disease (CAD): Systematic Review and Meta-analysis
Several studies have noted that vitamin D receptor (VDR) gene polymorphisms are involved in the susceptibility to Coronary artery disease (CAD)....
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Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Despite intensive research, considerable information on NAFLD development...
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Strategies for the Design of Vitamin D Receptor Ligands
Structure-activity relationship analysis is a powerful tool to elucidate the structural requirements for high-affinity vitamin D receptor (VDR)...
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Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation
BackgroundAlzheimer’s disease (AD) is the most common type of neurodegenerative disease in the contemporary era, and it is still clinically...
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Vitamin D and Gut Health
Vitamin D is a conditionally required nutrient that can either be obtained from skin synthesis following UVB exposure from the diet. Once in the...