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Expression of Circulating Rennin—Angiotensin—Aldosterone-Related microRNAs in Patients with Thyrotoxic Heart Disease
Thyrotoxic heart disease (THD) is a common and severe complication of hyperthyroidism and the etiology of this complication remains poorly...
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Renin Angiotensin System and Thyroid Hormone Crosstalk: From Experimental Approaches to Clinical Perspectives
The renin angiotensin systemRenin angiotensin system (RAS) plays a central role in the maintenance of regular cardiovascular functions and is...
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Case report of QT interval prolongation induced by anamorelin in an obese patient with non-small cell lung cancer
BackgroundAnamorelin, a drug to treat cancer cachexia, binds to ghrelin receptors and improves body weight and appetite. In clinical trials in Japan,...
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PD-1 Inhibitor-Induced Thyrotoxicosis Associated with Coronary Artery Spasm and Ventricular Tachycardia
Programmed cell death protein 1 (PD-1) inhibitors open a new era of cancer immunotherapy, but they are associated with immune-related adverse events...
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Oxidative Stress Biomarkers and Their Applications to Detect Excessive Fluorine
The review summarizes current data on the effects of fluoride ions on humans and mammals as well as current literature data on the molecular...
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Oxidative Stress Biomarkers and Their Applications to Detect Excessive Fluorine
The review summarizes current data on the effects of fluoride ions on humans and mammals as well as current literature data on the molecular...
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Adverse Effects of Phytochemicals
Phytochemicals are a wide variety of chemical compounds that are naturally produced by plants. Some phytochemicals are known as phytotoxins that are...
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Elucidating the role of phytocompounds from Brassica oleracea var. italic (Broccoli) on hyperthyroidism: an in-silico approach
Thyroid hormone (TH) plays a crucial role in regulating the metabolism in every cell and all organs in of the human body. TH also control the rate of...
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Scintigraphy evaluation of hyperthyroidism and its correlation with clinical and biochemical profiles
ObjectiveHyperthyroidism is the excessive synthesis of thyroid hormones. Thyroid uptake scans and ultrasonography provide an accurate diagnosis of...
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Syndromes of Resistance to Thyroid Hormone Action
Thyroid hormone (TH) action is crucial for the development of several tissues. A number of syndromes are associated with reduced responsiveness to...
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Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications
For the past two decades several scholarly reviews have appeared on the inwardly rectifying potassium (Kir) channels. We would like to highlight two...
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Pharmacodynamic Evaluation: Cardiovascular Methodologies
Cardiovascular methods to assess pharmacodynamics nowadays evolve very quickly, due to rapid progress in high technology and IT sector. Noteworthy,...
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Hypothalamus
A major function of the nervous system is to maintain the constancy of the internal environment. In 1878, Claude Bernard pointed out the remarkable...
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Thyrotoxic crisis presenting with jaundice
BackgroundThyrotoxic crisis is a medical emergency requiring early diagnosis and urgent management, which can be challenging due to its diverse...
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Drugs for Treatment of Thyroid Gland Diseases
The thyroid hormones T4 and T3 regulate nearly every body function. Thyrocytes take up iodide and incorporate it into tyrosine residues of...
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Prodrug Design to Enhance Bioavailability and Systemic Delivery
In the preceding two chapters in Section I, different strategies used to characterize the properties and performance of a drug, which can be either a...
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Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy,...
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Mutational Landscape of Resistance to Thyroid Hormone Beta (RTHβ)
Resistance to thyroid hormone beta (RTHβ) is a syndrome characterized by reduced responsiveness of peripheral tissues to thyroid hormone (TH). In...
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Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment
Human brown adipose tissue (BAT) is experimentally modeled to better understand the biology of this important metabolic tissue, and also to enable...
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Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications
Ion channels are macromolecular proteins that form water-filled pores in cell membranes and they are critical for a variety of physiological and...