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Natural and Experimental Sex Reversal in Birds and Other Groups of Vertebrates, with the Exception of Mammals
AbstractThe review is focused on the current problem of sex determination. Many research papers were devoted to this issue, but all the details of...
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High elevation increases the risk of Y chromosome loss in Alpine skink populations with sex reversal
The view that has genotypic sex determination and environmental sex determination as mutually exclusive states in fishes and reptiles has been...
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Sex differences in learning and performing the Go/NoGo tasks
BackgroundThe quality of learning and post-learning performances is critical for daily life. The behavioral flexibility is equally important for...
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Sex Differences in HIV Infection
Biological sex has wide-ranging impacts on HIV infection spanning differences in acquisition risk, the pathogenesis of untreated infection, impact of...
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Norepinephrine depletion in the brain sex-dependently modulates aspects of spatial learning and memory in female and male rats
RationaleThe contribution of norepinephrine on the different phases of spatial memory processing remains incompletely understood. To address this...
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Sex Differences in Pain with Emphasis on Neuroimmune Interactions
To date, the mechanisms underlying how neuroimmune interactions contribute to sex dimorphism of chronic pain remain elusive. Although women suffer...
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Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
BackgroundThe nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the...
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Sex Differences in Dementia
Background Women in many cohorts have a higher risk for Alzheimer’s disease (AD), the most common form of dementia....
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Conserved genes regulating human sex differentiation, gametogenesis and fertilization
The study of the functional genome in mice and humans has been instrumental for describing the conserved molecular mechanisms regulating human...
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A neural substrate of sex-dependent modulation of motivation
While there is emerging evidence of sex differences in decision-making behavior, the neural substrates that underlie such differences remain largely...
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DNA Methylation is Involved in Sex Determination in Spinach
DNA methylation plays a critical role in the modulation of gene expression. The role of DNA methylation in sex determination was investigated in...
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Sex and Gender Differences in Tuberculosis Pathogenesis and Treatment Outcomes
Tuberculosis remains a daunting public health concern in many countries of the world. A consistent observation in the global epidemiology of...
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Sex-specific differences in zebrafish brains
In this systematic review, we highlight the differences between the male and female zebrafish brains to understand their differentiation and their...
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Renal plasticity revealed through reversal of polycystic kidney disease in mice
Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs when kidney tubule cells are rendered null for either PKD1 ...
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Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer
BackgroundThere is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy. Here, we explored the...
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Gonadal Transcriptome Analysis Reveals that SOX17 and CYP26A1 are Involved in Sex Differentiation in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)
The Chinese soft-shelled turtle ( Pelodiscus sinensis ) is an important aquaculture animal in China and exhibits growth dimorphism. Single-male...
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Epigenetic mechanisms regulate sex-specific bias in disease manifestations
AbstractSex presents a vital determinant of a person’s physiology, anatomy, and development. Recent clinical studies indicate that sex is also...
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Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant...
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Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
It has recently become well-established that there is a connection between Alzheimer’s disease pathology and gut microbiome dysbiosis. We have...
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Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
BackgroundMonopterus albus is a hermaphroditic fish with sex reversal from ovaries to testes via the ovotestes in the process of gonadal...
