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Sex Differences in Pain with Emphasis on Neuroimmune Interactions

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Neuroimmune Interactions in Pain

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Abstract

To date, the mechanisms underlying how neuroimmune interactions contribute to sex dimorphism of chronic pain remain elusive. Although women suffer from chronic pain at greater rates than men, the current mechanistic understanding of chronic pain has been predominantly derived from the study of male animals. As such, a greater emphasis will be needed to investigate female-specific signaling mechanisms in chronic pain. These efforts will improve our understanding of sex dimorphism in chronic pain and improve the ability of pain medicine address specific patient backgrounds in the future. In this chapter, we will discuss pain-related sex differences in neural, immune, and glial mechanisms, with a focus on sex dimorphism in neuroimmune interactions.

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Authors and Affiliations

  1. Center for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC, USA

    **n Luo & Ru-Rong Ji

  2. Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, China

    **n Luo

  3. Wellesley College, Boston, MA, USA

    Jasmine Ji

  4. Departments of Cell Biology and Neurobiology, Duke University, Durham, NC, USA

    Ru-Rong Ji

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  1. **n Luo
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Editors and Affiliations

  1. Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA

    Ru-Rong Ji

  2. Pain Management and Neurosciences, Cleveland Clinic, Cleveland, OH, USA

    Jianguo Cheng

  3. Wellesley College, Wellesley, MA, USA

    Jasmine Ji

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Luo, X., Ji, J., Ji, RR. (2023). Sex Differences in Pain with Emphasis on Neuroimmune Interactions. In: Ji, RR., Cheng, J., Ji, J. (eds) Neuroimmune Interactions in Pain . Springer, Cham. https://doi.org/10.1007/978-3-031-29231-6_6

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