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Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis
BackgroundGeriatric people are prone to suffer from multiple chronic diseases, which can directly or indirectly affect renal function. Through...
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Comparative polymyxin B pharmacokinetics in critically ill patients with renal insufficiency and in continuous veno-venous hemodialysis
PurposeThe aim of this study was to assess polymyxin B pharmacokinetics (PK) in patients with varying degrees of renal dysfunction and in patients...
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Prevalence of renal insufficiency and factors associated among selected cancer patients on chemotherapy at Ocean Road Cancer Institute in Tanzania: a cross-sectional study
BackgroundCancer is among the leading cause of death worldwide. Chemotherapy is commonly used in cancer management and among the challenges in...
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Influence of renal insufficiency on anticoagulant effects and safety of warfarin in Chinese patients: analysis from a randomized controlled trial
This study aimed to analyze the influence of renal insufficiency on the anticoagulant effects and safety of warfarin in Chinese patients. Data on the...
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Deficiency of the mitochondrial ribosomal subunit, MRPL50, causes autosomal recessive syndromic premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a common cause of infertility in women, characterised by amenorrhea and elevated FSH under the age of...
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Associations of Blood and Cerebrospinal Fluid Aβ and tau Levels with Renal Function
Amyloid β (Aβ) and tau play pivotal roles in the pathogenesis of Alzheimer’s disease (AD). Previous studies have shown that brain-derived Aβ and tau...
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Pembrolizumab-induced secondary adrenal insufficiency due to adrenocorticotrophic hormone deficiency in a patient with non-small-cell lung carcinoma: a case report
BackgroundPembrolizumab can cause immune-related adverse events such as adrenal insufficiency (AI). However, there is no consensus regarding...
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Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy
The renal renin-angiotensin system (RAS) is involved in the development of chronic kidney disease. Here, we investigated whether mice with reduced...
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14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis
Acute kidney injury (AKI) refers to a group of common clinical syndromes characterized by acute renal dysfunction, which may lead to chronic kidney...
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An automatic segmentation framework for computer-assisted renal scintigraphy procedure
One of the techniques for achieving unique and reliable information in medicine is renal scintigraphy. A key step for quantitative renal scintigraphy...
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Physiologically based pharmacokinetic modeling of apixaban to predict exposure in populations with hepatic and renal impairment and elderly populations
BackgroundApixaban is a factor Xa inhibitor with a limited therapeutic index that belongs to the family of oral direct anticoagulants. The...
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Patients with metastatic renal cell carcinoma who receive immune-targeted therapy may derive survival benefit from nephrectomy
BackgroundNephrectomy, whether in the era of cytokine therapy or targeted therapy, has an important role in the treatment of metastatic renal cell...
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Polypharmacology in Clinical Applications: Renal Polypharmacology
The urinary system, also known as the renal system or urinary tract, consists of the kidneys ,...
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Influence of arterial blood gases on the renal arterial resistive index in intensive care unit
BackgroundRenal artery Doppler sonography with resistive index (RI) determination is a noninvasive, fast, and reliable diagnostic tool increasingly...
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Renal blood flow and oxygenation
Our kidneys receive about one-fifth of the cardiac output at rest and have a low oxygen extraction ratio, but may sustain, under some conditions,...
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The effect of renal impairment and obesity on anti-Xa peak and trough levels in patients receiving therapeutic doses of nadroparin: a comparison with control patients
PurposeAnti-Xa peak level monitoring is recommended during LMWH treatment in renal impairment or obesity. The trough level has been proposed as...
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Hemodynamic and neuromuscular basis of reduced exercise capacity in patients with end-stage renal disease
PurposeThe present study aimed to characterize the exercise-induced neuromuscular fatigue and its possible links with cerebral and muscular oxygen...
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Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis
BackgroundLinezolid causes hematological toxicity, mostly thrombocytopenia, which leads to treatment discontinuation and failure. Recent studies...
