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Purinergic P2X Receptors as Therapeutic Targets
Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three...
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P2 purinergic receptors regulate the progression of colorectal cancer
More and more studies have revealed that P2 purinergic receptors play a key role in the progression of colorectal cancer (CRC). P2X and P2Y...
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The functional role of P2 purinergic receptors in the progression of gastric cancer
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cells and GC tissues and...
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Purinergic P2 Receptors in Epilepsy
Despite continuous advances in the understanding of the underlying pathogenesis of hyperexcitable networks and lowered seizure threshold, treatment...
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Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend their functions beyond the cell. In this context, purinergic...
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Roles of Purinergic Receptors in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by major memory impairments. Neuropathologically, AD is defined by the...
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Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors
Transactivation of receptor tyrosine kinases (RTK) is a crosstalk mechanism exhibited by G-protein–coupled receptors (GPCR) to activate signaling...
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Cross Talk on P2X4 Purinergic Receptors and Neuropathic Pain
Purpose of ReviewConsiderable interest has been paid to purinergic receptors, a group of cell surface receptors that react to extracellular purines...
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Scrutinizing the Therapeutic Promise of Purinergic Receptors Targeting Depression
Antidepressant use has resulted in a variety of negative consequences, including permanent brain damage and erectile dysfunction. So, the purpose...
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Purinergic Signaling in Depression
Depressive disorders are thought to result from a complex interplay between genetic and environmental factors, of which stress seems to play a...
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Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure
Heart failure is associated with multiple mechanisms, including sympatho-excitation, and is one of the leading causes of death worldwide. Enhanced...
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Purinergic Signaling in Neuroinflammation
Neuroinflammation is a process induced by the innate immune system and involves the activation of resident immune cells of the CNS, such as...
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Purinergic regulation of pulmonary vascular tone
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising avenue for addressing lung...
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Microglial purinergic signaling in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease. The prevalent features of AD pathogenesis are the appearance of...
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Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats
Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of...
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Purinergic Signaling in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder estimated to affect 1:36 individuals, characterized by impairments...
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Purinergic Signaling in Parkinson’s Disease
Alterations in the brain basal ganglia compromise diverse neurological processes. The main symptoms are related to motor and mood control. The system...
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Purinergic Signaling: An Overview
This chapter summarizes some of the evidence that originated the purinergic signaling discovery from the first identification of purines and...
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Targeting purinergic receptors to attenuate inflammation of dry eye
Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that...
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Purinergic Signaling in the Cerebellum
Purinergic signaling is a complex and evolutionarily conserved mechanism of extracellular communication involved in many physiological and...