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Stability and Characterization of Protein- and Nucleotide-Based Therapeutics
Throughout the development process of protein or nucleotide-based therapeutics, a broad array of analytical techniques is applied on a routine basis...
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Stability of Protein Pharmaceuticals: Recent Advances
There have been significant advances in the formulation and stabilization of proteins in the liquid state over the past years since our previous...
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Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability
BackgroundHuman polyomavirus BK (BKPyV) causes associated nephropathy and contributes to urinary tract cancer development in renal transplant...
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The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth
PurposeMethylenetetrahydrofolate dehydrogenase (MTHFD1), a key enzyme on the folate pathway, has been implicated in the tumor development of distinct...
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Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease
Protein function can be impacted by changes in protein structure stability, but determining which change has impact is complex. Stability can be...
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UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability
BackgroundRenal interstitial fibrosis is a common pathway for the progressive development of chronic renal diseases (CKD) with different etiology,...
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Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis
BackgroundGRP78 has been implicated in hepatocarcinogenesis. However, the clinical relevance, biological functions and related regulatory mechanisms...
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Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR
BackgroundBreast cancer (BC) is the most common malignant disease in female patients worldwide. In HER-2+ BC patients, trastuzumab therapy is...
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Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein
SNHG4 is a lncRNA that was previously reported to promote colorectal cancer (CRC) progression via molecular sponge mechanism. Bioinformatic analysis...
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Impact of Extractables/Leachables from Filter Materials on the Stability of Protein-Based Pharmaceutical Products
The manufacturing of biopharmaceutical drug solutions can involve close contact with various polymeric components, including common filter membranes....
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Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification
RNA binding proteins (RBPs) are crucial for cell function, tissue growth, and disease development in disease or normal physiological processes. RNA...
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Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose
This study examined the effect of buffer salts on the physical stability of spray-dried and lyophilized formulations of a model protein, bovine serum...
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Impact of Different Saccharides on the In-Process Stability of a Protein Drug During Evaporative Drying: From Sessile Droplet Drying to Lab-Scale Spray Drying
ObjectivesSolid biopharmaceutical products can circumvent lower temperature storage and transport and increase remote access with lower carbon...
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Structural Consequences of IRS-2 nsSNPs and Implication for Insulin Receptor Substrate-2 Protein Stability
Single-Nucleotide Polymorphisms (SNPs) are common genetic variations implicated in human diseases. The non-synonymous SNPs (nsSNPs) affect the...
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Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations
PurposePolysorbate excipients are commonly used as surfactants to stabilize therapeutic proteins in formulations. Degradation of polysorbates could...
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The deubiquitinating enzyme USP4 regulates BRCA1 stability and function
BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability,...
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Luminescence-Based Techniques for KRAS Thermal Stability Monitoring
Various biochemical methods have been introduced to detect and characterize KRAS activity and interactions, from which the vast majority is based on...
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The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability
Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is associated with poor prognosis, aggressive malignant behavior, and...
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Assessing and Engineering Antibody Stability Using Experimental and Computational Methods
Engineering increased stability into antibodies can improve their developability. While a range of properties need to be optimized, thermal stability...
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Protein Nanocarriers for the Delivery of Phytoconstituents
Phytoconstituents are well known for their anticancer activities. They are considered as the best alternatives of chemotherapeutic drugs because of...