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Preclinical Methods of Neurosteroid-Induced Facilitation of Fear Extinction and Fear Extinction Retention
Post-traumatic stress disorder and other stress-related mood disorders are a major public health burden. Psychotherapy and SSRIs, the only...
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Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury
Traumatic brain injury (TBI) triggers wide-ranging pathology that impacts multiple biochemical and physiological systems, both inside and outside the...
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Gestational Exposure to Di-n-Butyl Phthalate Induces Autism-Like Behavior Through Inhibition of Neuro-Steroidogenesis
Di-n-butyl phthalate (DBP) is one of the most dominant phthalate esters and is a widely distributed environmental contaminant. The endocrine...
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Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue
BackgroundCausative genetic variants cannot yet be found for many disorders with a clear heritable component, including chronic fatigue disorders...
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Population-based case-control study revealed metabolomic biomarkers of suboptimal health status in Chinese population—potential utility for innovative approach by predictive, preventive, and personalized medicine
BackgroundSuboptimal health status (SHS) is a subclinical stage of chronic diseases, and the identification of SHS provides an opportunity for the...
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Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to...
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Animal Model Approaches to Understanding the Neurobiology of Suicidal Behavior
Severe psychiatric conditions, including major depressive disorder (MDD) and post-traumatic stress disorder (PTSD), are characterized by a strong...
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Neurosteroids and Depression
Abstract— Neurosteroids are steroids that rapidly alter neuronal excitability by interacting with cell surface receptors, mainly the GABA/A receptor...
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Neuroactive Steroids
Neuroactive steroids regulate neuronal and glial function via non-genomic mechanisms by interacting with ion channels and neurotransmitter receptors....
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The effects of gonadal hormones on heroin Self-Administration in male gonadectomized rats
RationalePrevious studies have shown that gonadal hormones influence opioid self-administration in female rodents, but very few studies have examined...
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The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders
Peroxisome proliferator-activated receptors (PPARs) are nonsteroid nuclear receptors and transcription factors that regulate several...
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Maternal Recognition of Pregnancy
Hormone-induced adaptations occur in many aspects of maternal physiology during gestation. Before these changes can be initiated, the newly formed...
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Neuroendocrinology of Perinatal Mental Illness
Mental illness during pregnancy and the postpartum period is a growing health crisis. We know that at least 1 in 7 women during the perinatal...
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Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors (NMDAR) on hypothalamic...
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Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
BackgroundType 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the...
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Effects of Acute Swimming Stress on the Behavioral and Neurochemical Effects of Pyrazolo[C]pyridine Derivative GIZh-72 and Diazepam in BALB/c and C57BL/6 Mice
The effects of acute swimming stress (ASS) on the behavioral and neurochemical actions of a pyrazolo[C]pyridine derivative GIZh-72 (20 mg/kg, i.p.)...
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Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
RationaleChronic alcohol intake down-regulates GABAergic transmission and reduces levels of neuroactive steroids. These changes are associated with...
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Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers associated with treatment response of neoadjuvant therapy with TCbHP regimen in HER2 + breast cancer
BackgroundThis study aimed to explore potential indicators associated with the neoadjuvant efficacy of TCbHP regimen (taxane, carboplatin,...
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Gas Chromatography–Mass Spectrometry Analysis of Urinary Steroid Metabolomics for Detection of Early Signs of Adrenal Neoplasm Malignancy in Patients with Cushing’s Syndrome
The metabolomics of urinary steroids was studied by gas chromatography-mass spectrometry in 25 patients with Cushing’s syndrome without malignant...
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Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system
Sex steroid hormones influence olfactory-mediated social behaviors, and it is generally hypothesized that these effects result from circulating...
