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The Scope of Mendelian Cardiomyopathy Genes
AbstractThe review analyses the scope of the genes of Mendelian cardiomyopathies (CM), specifically hypertrophic, dilated, arrhythmogenic, and...
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Understanding the molecular mechanisms of statin pleiotropic effects
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic cardiovascular disease. These medications not only reduce...
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On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy
The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic...
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Human Genetics of Ventricular Septal Defect
Ventricular septal defects (VSDs) are recognized as one of the commonest congenital heart diseases (CHD), accounting for up to 40% of all cardiac...
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Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility
Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular disease (CVD) deaths in the USA and around the globe....
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Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function
Right ventricular (RV) structure and function influence the morbidity and mortality from coronary artery disease (CAD), dilated cardiomyopathy (DCM),...
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Nuclear speckleopathies: developmental disorders caused by variants in genes encoding nuclear speckle proteins
Nuclear speckles are small, membrane-less organelles that reside within the nucleus. Nuclear speckles serve as a regulatory hub coordinating complex...
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The beneficial health effects of puerarin in the treatment of cardiovascular diseases: from mechanisms to therapeutics
Cardiovascular diseases (CVDs) are the leading causes of death globally that seriously threaten human health. Although novel western medicines have...
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“Mendelian Code” in the Genetic Structure of Common Multifactorial Diseases
AbstractThe phenomenon of comorbidity between monogenic and multifactorial diseases suggests the involvement of a certain common number of genes and...
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Genome-first approach to rare EYA4 variants and cardio-auditory phenotypes in adults
While newborns and children with hearing loss are routinely offered genetic testing, adults are rarely clinically tested for a genetic etiology. One...
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Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications
Curcumin is a polyphenolic compound derived from turmeric that has potential beneficial properties for cardiovascular and renal diseases and is...
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Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature
Fibrosis is a process of pathological tissue repair that replaces damaged, formerly functional tissue with a non-functional, collagen-rich scar....
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Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
The laboratory rat has been used for a long time as the model of choice in several biomedical disciplines. Numerous inbred strains have been...
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FoxO3 and oxidative stress: a multifaceted role in cellular adaptation
Oxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass...
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Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction
Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding...
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Therapeutic Use of Interferon Gamma in Friedreich Ataxia
Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by GAA triplet expansion in the FXN gene. At the cellular level, FRDA...
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Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological relationship between cardiovascular diseases and cancer....
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Therapeutics in Metabolic Diseases
Metabolic diseases have important effects on the health and healthcare costs of an individual. It adversely affects various body processes. Metabolic...
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Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA),...
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MicroRNA-126 (MiR-126): key roles in related diseases
In eukaryotes such as humans, some non-coding single-stranded RNAs (ncRNAs) help to regulate the pre- and post-transcriptional expression of certain...
