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Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
BackgroundPericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently suggested. However, it...
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Platelet-Derived Extracellular Vesicles in Disease Therapy
Platelets are vesicle-related cells in the blood. Indeed, platelets are regarded as vesicles themselves because they do not contain nuclei, and they...
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The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma
Platelet-rich plasma (PRP) is a biological blood-derived therapeutic obtained from whole blood that contains higher levels of platelets. PRP has been...
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Topical phenytoin administration accelerates the healing of acetic acid-induced colitis in rats: evaluation of transforming growth factor-beta, platelet-derived growth factor, and vascular endothelial growth factor
Ulcerative colitis (UC), limited to the colon’s innermost lining, has become a global health problem. Immunomodulatory and monoclonal antibodies are...
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Platelet-Derived Extracellular Vesicles in Arterial Thrombosis
Blood platelets are necessary for normal haemostasis but also form life-threatening arterial thrombi when atherosclerotic plaques rupture. Activated...
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Differential Expression of the hTERT Gene in Umbilical Cord-Derived Mesenchymal Stem Cells Cocultured with B Cell Precursor Leukemia Cell Microparticles or CD41+/CD61+ Platelet Microparticles
Several investigations are being done to increase the short lifetime of mesenchymal stem cells (MSCs). One of the crucial genes involved in the...
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Expression of Vascular Endothelial Growth Factor at High Altitude
Oxygen plays an important role in aerobic respiration in mammals. However, there is subsequent decrease in partial pressure of oxygen with increase...
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Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor A: Biomarkers Potential in Diabetes
Previously, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) have been studied only in diabetic neuropathy or...
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Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair
The failure of cartilage healingHealing is a major impediment to recovery from jointJoint diseaseDisease or trauma. Growth factors play a central...
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Temporal dynamics of cells expressing NG2 and platelet-derived growth factor receptor-β in the fibrotic scar formation after 3-nitropropionic acid-induced acute brain injury
Neuron-glia antigen 2 (NG2) proteoglycan and platelet-derived growth factor receptor beta (PDGFR-β) are widely used markers of pericytes, which are...
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Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity
Platelet-derived growth factor-B (PDGF-B) is a main factor to promote adipose tissue angiogenesis, which is responsible for the tissue expansion in...
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Analysis of platelet-derived growth factor receptor A and oligodendrocyte transcription factor 2 markers following Hydroxychloroquine administration in animal induced multiple sclerosis model
It has been shown that following demyelination, Oligodendrocyte Progenitor Cells (OPCs) migrate to the lesion site and begin to proliferate, and...
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Transforming growth factor-β receptors: versatile mechanisms of ligand activation
Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane TGF-β receptors (TGFBR), which deploys Smad2/3...
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Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
BackgroundBioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and...
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Brain-derived neurotrophic factor and vascular endothelial growth factor A: biomarkers potential in diabetes
Previously, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) have been studied only in diabetic neuropathy or...
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The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their...
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The effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampal oxidative-nitrosative stress, and histological changes induced by icv-STZ in a rat model
Impaired insulin and growth factor functions are thought to drive many alterations in neurodegenerative diseases like dementia and seem to contribute...
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Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways
Myelin-forming oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) are essential for...
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Hematopoietic Growth Factors
Hematopoiesis is an intricate, well-regulated, and homeostatic multistep process that allows immature precursor cells in the bone marrow to...
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Growth Factor Roles in Soft Tissue Physiology and Pathophysiology
Repair and healing of injured and diseased tendons has been traditionally fraught with apprehension and difficulties, and often led to rather...