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Peptide Therapeutics Fundamentals of Design, Development, and Delivery
This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as...
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Advances in Peptide Synthesis
Peptide drug development has made significant progress over the last century. The discovery of solid-phase peptide synthesis has enabled chemists to...
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A Brief Insight into Peptide and Non-Peptide Drugs of Fungal Origin
Microorganisms are valuable resources for obtaining bioactive compounds, which have proven to be very useful in various domains, e.g., agriculture,...
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Porous silicon and silica carriers for delivery of peptide therapeutics
Peptides have gained tremendous popularity as biological therapeutic agents in recent years due to their favourable specificity, diversity of...
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Regulatory Issues for Peptide Drugs
Peptides have characteristics of both proteins and small molecules, making them specific to bind to a target, similar to endogenous molecules....
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Peptide aptamer-based time-resolved fluoroimmunoassay for CHIKV diagnosis
BackgroundChikungunya virus (CHIKV) and Dengue virus (DENV) have similar clinical symptoms, which often induce misdiagnoses. Therefore, an antigen...
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Peptide Synthesis: Methods and Protocols
The development of the field of peptide synthesis has been integral in studying their physiological role in living systems as well as their use in...
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Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies
Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in...
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Self-assembled peptide/polymer hybrid nanoplatform for cancer immunostimulating therapies
Integrating peptide epitopes in self-assembling materials is a successful strategy to obtain nanovaccines with high antigen density and improved...
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Nanocarriers for Delivery of Peptide Antibiotics
Bacterial infections pose a major threat to public health due to continuous bacterial growth and their resistance to conventional antibiotics. The...
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Peptide-Based HIV Entry Inhibitors
The development of peptide-based HIV entry inhibitors has made an important contribution to the stock of anti-HIV drugs. In particular, the...
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Efficacy of MAGE-A4 long peptide as a universal immunoprevention cancer vaccine
BackgroundThe clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently...
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Reference Standards to Support Quality of Synthetic Peptide Therapeutics
PurposePeptides are an important class of therapeutics. Their quality is evaluated using a series of analytical tests, many of which depend on...
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Strategies to improve the physicochemical properties of peptide-based drugs
Peptides are a rapid-growing class of therapeutics with unique and desirable physicochemical properties. Due to disadvantages such as low membrane...
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DeepHLApan: A Deep Learning Approach for the Prediction of Peptide-HLA Binding and Immunogenicity
Neoantigens are crucial in distinguishing cancer cells from normal ones and play a significant role in cancer immunotherapy. The field of...
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Dual-function antimicrobial-antibiofilm peptide hybrid to tackle biofilm-forming Staphylococcus epidermidis
BackgroundDue to their resistance and difficulty in treatment, biofilm-associated infections are problematic among hospitalized patients globally and...
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Gonorrhea caused due to antimicrobial-resistant bacteria Neisseria gonorrhoeae treated using probiotic peptide
Neisseria gonorrhea is a sexually transmitted disease from gonorrhea that lacks treatment; despite the urgency, the absence of adequate drugs, lack...
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Particle bombardment-assisted peptide-mediated gene transfer for highly efficient transient assay
ObjectiveA centrifugation-assisted peptide-mediated gene transfer (CAPT) method was recently developed as an efficient system for gene delivery into...
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Effects of Gly-His-Lys-D-Ala Peptide on Skin Wound Regeneration Processes
We evaluated the effects of the Gly-His-Lys-D-Ala peptide in a dose 0.5 μg/kg on skin wound regeneration in male Wistar rats ( n =80) after initial...