Search
Search Results
-
Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions
Neutrophils are the essential guards of the immune system that inactivate different pathogens as well as instruct specific immune responses. Nitric...
-
Nitric Oxide Regulation in Microparticles
Nitric oxide (NO) has been widely shown to have a varied roles physiologically. Nitric oxide presence in microparticle has been gaining importance...
-
-
Repurposing nitric oxide donating drugs in cancer therapy through immune modulation
BackgroundNitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less...
-
Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
BackgroundPruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...
-
Translating Nitric Oxide Research to Therapeutics: A Critical Appraisal
Nitric oxide (NO) is a signaling molecule with an extensive range of functions in both health and disease. Initially proposed as a regulator of...
-
Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway
Cholestasis describes bile secretion or flow impairment, which is clinically manifested with fatigue, pruritus, and jaundice. Neutrophils play a...
-
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challenges and high relapse rates....
-
Nitric Oxide as a Diagnostic and Therapeutic Tool in Respiratory Diseases
Nitric oxide (NO) is a gasotransmitter that plays a vital role in diverse biological processes. NO is a fundamental component in regulating...
-
The Role of Nitric Oxide in the Etiopathogenesis of Preeclampsia
Preeclampsia (PE) is a severe pregnancy complication that presents mostly after twenty weeks of gestation. It can be diagnosed by increased systolic...
-
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke
Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the...
-
The Negative Impact of Cancer Cell Nitric Oxide on Photodynamic Therapy
Numerous studies have shown that low-flux nitric oxide (NO) in tumors produced mainly by inducible nitric oxide synthase (iNOS/NOS2) can signal for...
-
Redox signaling-mediated tumor extracellular matrix remodeling: pleiotropic regulatory mechanisms
BackgroundThe extracellular matrix (ECM), a fundamental constituent of all tissues and organs, is crucial for sha** the tumor microenvironment....
-
Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling
Amphotericin B (AmB)–induced acute kidney injury (AKI) is a common health problem having an undesirable impact on its urgent therapeutic utility for...
-
Role of Nitric Oxide Synthases in Doxorubicin-Induced Cardiomyopathy
Since the discovery of Doxorubicin (Dox), its safe use is under intense discussion due to its cardiotoxic side effects manifested in patients at...
-
ROS Signaling in Brain Tumor
The heterogeneous cell population of the brain tumor and its microenvironment is a significant challenge to the current treatment modalities of...
-
ROS Signaling in Brain Tumor
The heterogeneous cell population of the brain tumor and its microenvironment is a significant challenge to the current treatment modalities of...
-
Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications
MotivationOvarian cancer (OC) is a highly lethal gynecological malignancy. Extensive research has shown that OC cells undergo significant metabolic...
-
Chronic Cinacalcet improves skin flap survival in rats: the suggested role of the nitric oxide pathway
Cinacalcet is a calcimimetic medicine that has been used to treat secondary hyperparathyroidism and parathyroid cancer. Various studies have proposed...
-
Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter
We studied the effect of nitric oxide (NO) on the functioning of P-glycoprotein transporter (Pgp) in Caco-2 cells. NO donor S-nitrosoglutathione...