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Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions

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Nitric Oxide: From Research to Therapeutics

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 22))

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Abstract

Neutrophils are the essential guards of the immune system that inactivate different pathogens as well as instruct specific immune responses. Nitric oxide (NO), a pleiotropic signaling molecule produced from nitric oxide synthases, regulates neutrophils at diverse levels. This includes the development of neutrophils from hematopoietic stem cells through granulopoiesis processes; furthermore, nitric oxide regulates neutrophil maturation from committed progenitor cells. In addition, nitric oxide regulates most of the neutrophil functions, such as adhesion, chemotaxis, respiratory burst, apoptosis, NETosis, intruder killing, and tissue damage. Intriguingly, neutrophils provide substantial amount of NO with the presence of nitric oxide synthases and their regulation in inflammatory conditions. Overall, this work discusses the role of nitric oxide signaling in neutrophil ontogeny and functions.

Sachin Kumar and Samreen Sadaf authors have contributed equally

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Authors and Affiliations

  1. Pharmacology Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India

    Sachin Kumar, Samreen Sadaf & Madhu Dikshit

  2. THSTI National Chair, Translational Health Science and Technology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad–Gurgaon Expressway, Faridabad, Haryana, 121001, India

    Madhu Dikshit

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  1. Sachin Kumar
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  2. Samreen Sadaf
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  3. Madhu Dikshit
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Correspondence to Madhu Dikshit .

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Editors and Affiliations

  1. Department of Pharmacology, Hamdard Institute of Medical Sciences and Research, Hamdard University, New Delhi, India

    Arunabha Ray

  2. Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India

    Kavita Gulati

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Kumar, S., Sadaf, S., Dikshit, M. (2023). Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions. In: Ray, A., Gulati, K. (eds) Nitric Oxide: From Research to Therapeutics. Advances in Biochemistry in Health and Disease, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-031-24778-1_8

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