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Trimethylamine-N-oxide, a New Risk Factor for Non-alcoholic Fatty Liver Disease Changes the Expression of miRNA-34a, and miRNA-122 in the Fatty Liver Cell Model
Non-alcoholic fatty liver disease is a multifactorial disorder with complicated pathophysiology ranging from simple steatosis to steatohepatitis and...
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miR-34a mimic or pre-mir-34a, which is the better option for cancer therapy? KatoIII as a model to study miRNA action in human gastric cancer cells
BackgroundAberrantly expressed microRNAs play important roles in gastric tumorigenesis. However, use of miRNAs as a therapeutic option in gastric...
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Communication in miRNAs Between Inflammation and Cancer
Inflammatory and immune responses are controlled by microRNAs (miRNAs), and cancer is also regulated by miRNAs. Computing analysis and evidence from...
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miR-34a-5p as molecular hub of pathomechanisms in Huntington’s disease
BackgroundAlthough a pivotal role of microRNA (miRNA, miR) in the pathogenesis of Huntington’s disease (HD) is increasingly recognized, the molecular...
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An In Vitro Study for the Role of Schizophrenia-Related Potential miRNAs in the Regulation of COMT Gene
This study aimed to analyze the possible association of miR-30a-5p, miR-30e-5p, and miR-34a-5p identified as potential candidate miRNAs in...
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Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs
MicroRNAs (miRNAs), molecules comprising 18–22 nucleotides, regulate expression of genes post-transcriptionally at the 3′ untranslated region of...
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miR-34a/TAN1/CREB Axis Engages in Alleviating Oligodendrocyte Trophic Factor-Induced Myelin Repair Function and Astrocyte-Dependent Neuroinflammation in the Early Stages of Alzheimer's Disease: The Anti-Neurodegenerative Effect of Treadmill Exercise
Reduced myelin stability observed in the early stages of Alzheimer's disease leads to spatial learning and memory impairment. Exercise has been shown...
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Synthetic miR-34a against solid tumours: a predictable failure
A prolific scientific literature attributes pro- or anti-oncogenic properties to many human microRNAs (“miRNAs”). While many of these studies are...
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Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA
BackgroundVery few proteins encoded by the presumed non-coding RNA transcripts have been identified. Their cellular functions remain largely unknown....
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The E6 and E7 proteins of beta3 human papillomavirus 49 can deregulate both cellular and extracellular vesicles-carried microRNAs
BackgroundThe β3 human papillomavirus (HPV)49 induces immortalization of primary keratinocytes through the action of E6 and E7 oncoproteins with an...
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Plasma expression of miRNA-21, − 214, −34a, and -200a in patients with persistent HPV infection and cervical lesions
BackgroundTo examine differences in the plasma levels of miRNA-21, − 214, −34a, and -200a in patients with persistent high-risk human papillomavirus...
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Tirzepatide prevents neurodegeneration through multiple molecular pathways
BackgroundSeveral evidence demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes...
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Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews
BackgroundCross-species transmission of zoonotic IAVs to humans is potentially widespread and lethal, posing a great threat to human health, and...
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miRNA Therapy in Laboratory Models of Acute Spinal Cord Injury in Rodents: A Meta-analysis
miRNA therapy is popularly investigated in treating acute spinal cord injury (SCI) and offers a significant prospect for the treatment of acute SCI....
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Systematic review of circulating MICRORNAS as biomarkers of cervical carcinogenesis
BackgroundCervical cancer is a preventable disease, but it is a major public health problem despite having a good prognosis when diagnosed early....
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Molecular functions of microRNAs in colorectal cancer: recent roles in proliferation, angiogenesis, apoptosis, and chemoresistance
MiRNAs (microRNAs) constitute a group of diminutive molecules of non-coding RNA intricately involved in regulating gene expression. This regulation...
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Integrative Analysis of the Expression of microRNA, Long Noncoding RNA, and mRNA in Osteoarthritis and Construction of a Competing Endogenous Network
This study aimed to identify potential core microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and mRNAs in osteoarthritis (OA) to construct a...
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Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions
Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding...
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Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer
BackgroundBladder cancer (BC) has the highest per-patient cost of all cancer types. Hence, we aim to develop a non-invasive, point-of-care tool for...
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MicroRNAs as Potential Biomarkers of Type 2 Diabetes Mellitus
AbstractMicroRNAs are small noncoding RNAs involved in post-transcriptional regulation of gene expression. In recent years, works demonstrating...
