Abstract
Inflammatory and immune responses are controlled by microRNAs (miRNAs), and cancer is also regulated by miRNAs. Computing analysis and evidence from experimental and clinical investigations show that miRNAs can regulate most protein-coding genes. In contrast, cancer is implicated in proliferation, development, differentiation, apoptosis, inflammation, and the immune response, all of which miRNAs can modulate. In 2000, cancer and inflammation were assessed as separate issues. However, 10 years after RNA Wave 2000, it was reported that the tumor suppressive miR-34a suppressed the expression of the natural killer cell immunoreceptor NKG2D ligand (NKG2DL) ULBP2, suggesting that miR-34a may play a role in tumorigenesis and innate immune surveillance. Furthermore, oncogenic miR-155 contributes to the expression of IL-8 in pulmonary cystic fibrosis, suggesting that miRNA genes serve pleiotropic functions between cancer and inflammation. In November 2021, Google Scholar found 1574 miR-155 issues related to cancer and 895 issues related to immunity for a total hit count of 3727. miR-34a and miR-155 are biomarkers of colorectal cancer development and progression, and both miRNAs are secreted into the circulation; therefore, rectal cancer development and immune modulation are regulated by mobile miRNA genes. A major source of circulating exogeneous miRNAs (exomiRNAs) may come from foods. Thus, food xenotropic miRNAs (xenomiRNAs) may become communication tools, after which the environment may control both tumorigenesis and the immune system according to a new central dogma, the RNA Wave. Quantum miRNA immunity in 2020 and quantum miRNA surveillance were discovered in 2022 by miRNA entangling target sorting (METS)/miRNA quantum language and artificial intelligence (MIRAI).
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von Goethe, J. W.
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Fujii, Y.R. (2023). Communication in miRNAs Between Inflammation and Cancer. In: The MicroRNA 2000 Transformer. Springer, Singapore. https://doi.org/10.1007/978-981-99-3165-1_7
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