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MiR-106b-5p Attenuates Neuropathic Pain by Regulating the P2X4 Receptor in the Spinal Cord in Mice
The P2X4 receptor (P2X4R) can be upregulated after nerve injury, and its mediated spinal microglial activation makes a critical contribution to...
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MiR-106b-5p regulates esophageal squamous cell carcinoma progression by binding to HPGD
BackgroundSeveral studies have documented the key role of microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Although the expression of...
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Modulation of Microglia M2 Polarization and Alleviation of Hippocampal Neuron Injury By MiR-106b-5p/RGMa in a Mouse Model of Status Epilepticus
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level. The miRNA miR-106b-5p has been linked to epilepsy, but its specific...
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miR-106b-5p upregulation is associated with microglial activation and inflammation in the mouse hippocampus following status epilepticus
To investigate the association of miR-106b-5p with neuroinflammation and microglial activation in a status epilepticus (SE) mouse model. We examined...
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Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4
BackgroundCancer-secreted exosomal miRNAs regulates the biological processes of many tumours. The serum level of exosomal miR-106b-5p is...
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Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis
Temporal lobe epilepsy (TLE) is common intractable epilepsy that affects the patient’s lives. The circular RNA circ_ANKMY2 (circ_ANKMY2) has been...
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Exploration of microRNA-106b-5p as a therapeutic target in intervertebral disc degeneration: a preclinical study
MicroRNA (miRNA) has emerge as a vital regulator in the pathogenesis of intervertebral disc degeneration (IDD). However, miR-106b-5p expression in...
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Tumor-derived small extracellular vesicles promote breast cancer progression by upregulating PD-L1 expression in macrophages
BackgroundThe metastasis of breast cancer (BC) is a complex multi-step pathological process, strictly dependent on the intrinsic characteristics of...
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The Fibroblast-Like Synoviocyte Derived Exosomal Long Non-coding RNA H19 Alleviates Osteoarthritis Progression Through the miR-106b-5p/TIMP2 Axis
Osteoarthritis (OA) is a common degenerative joint disease that affects people worldwide. The interaction between fibroblast-like synoviocytes (FLSs)...
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Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews
BackgroundCross-species transmission of zoonotic IAVs to humans is potentially widespread and lethal, posing a great threat to human health, and...
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Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma
BackgroundTrabecular meshwork (TM) dysfunction-induced elevation of intraocular pressure has been identified as the main risk factor of irreversible...
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A review on the role of PTENP1 in human disorders with an especial focus on tumor suppressor role of this lncRNA
PTENP1 is a long non-coding RNA which has been regarded as a pseudogene of the PTEN tumor suppressor gene. However, it has been shown to be a...
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Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation
BackgroundsNon-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities...
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A systematic review of microRNAs as potential biomarkers for diagnosis and prognosis of gastric cancer
Gastric cancer (GC) is the third leading cause of global cancer morbidity and mortality. One of the significant challenges in GC treatment is that...
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Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma
Endometrial cancer (EC) is a major cause of death among gynecologic malignancies. To improve early detection of EC in patients, we carried out a...
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CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity
BackgroundCirrhosis is a recognized risk factor for develo** hepatocellular carcinoma (HCC). Few studies have reported the expression profile of...
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A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study
BackgroundCurrently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein,...
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Synovial fibroblast-derived exosomal microRNA-106b suppresses chondrocyte proliferation and migration in rheumatoid arthritis via down-regulation of PDK4
AbstractFibroblast-derived exosomes have been reported to transfer microRNAs to recipient cells, where they regulate target gene expression, which is...
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Expression Profile and Relationships between microRNAs as Biomarkers in COPD Patients
AbstractChronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes airflow obstruction in the lungs. In fact, it is a...
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Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway
Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D...
