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Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages
ObjectiveThis study aims to establish a Flow-through Visualization Dissolution System (FVDS) that combines time-lapse macro-imaging and a...
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Coupling Drug Dissolution with BCS
PurposeThe purpose of this study is to develop a Temporal Biopharmaceutic Classification System (T-BCS), linking Finite Dissolution Time (F.D.T.) and...
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A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
PurposeWe aim to present a refined thin-film model describing the drug particle dissolution considering radial diffusion in spherical boundary layer,...
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A Simple One-Parameter Percent Dissolved Versus Time Dissolution Equation that Accommodates Sink and Non-sink Conditions via Drug Solubility and Dissolution Volume
In vitro dissolution generally involves sink conditions, so dissolution equations generally do not need to accommodate non-sink conditions. Greater...
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In vitro Dissolution Testing of Rifampicin Powder Formulations For Prediction of Plasma Concentration–Time Profiles After Inhaled Delivery
PurposeThe purpose of this study was to evaluate the in vitro lung dissolution of amorphous and crystalline powder formulations of rifampicin in...
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PhysioCell — a Novel, Bio-relevant Dissolution Apparatus: Hydrodynamic Conditions and Factors Influencing the Dissolution Dynamics
The physiologically relevant dissolution apparatuses simulate various aspects of gastrointestinal physiology and help to understand and predict the in...
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Dependence of Bioavailability on Mean Absorption Time: What Does It Tell Us?
The extent and rate of bioavailability are fundamental measures to characterize the pharmacokinetics of drugs after oral administration. Together...
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Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets
Background and ObjectivesUnderstanding the processes that determine the time course of drug absorption rates is of great interest. This study aims to...
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Solubility vs Dissolution in Physiological Bicarbonate Buffer
BackgroundPhosphate buffer is often used as a replacement for the physiological bicarbonate buffer in pharmaceutical dissolution testing, although...
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Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
The use of apex vessels may solve coning problems associated with dissolution testing. However, excessive dissolution acceleration can reduce the...
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Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer
PurposeThe purpose of this study was to clarify the extent to which the dissolution profiles of immediate release (IR) products of various drugs...
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Dissolution Profile Similarity Assessment—Best Practices, Decision Trees and Global Harmonization
During the write-up of the meeting summary reports from the 2019 dissolution similarity workshop held at the University of Maryland’s Center of...
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Conventional vs Mechanistic IVIVC: A Comparative Study in Establishing Dissolution Safe Space for Extended Release Formulations
The use of in vitro - in vivo correlation (IVIVC) for extended release oral dosage forms is an important technique that can avoid potential clinical...
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Dissolution Profiles of Poorly Soluble Drug Salts in Bicarbonate Buffer
PurposeThe purpose of the present study was to investigate the effect of buffer species on the dissolution profiles of poorly soluble drug salts,...
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The Effect of Sampling Cannula on In Vitro Dissolution Testing with USP Paddle Method
In vitro dissolution tests are widely used as quality control tools for drug products in development and manufacturing. Dissolution acceptance...
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Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract
Inhalation is a portal-of-entry for aerosols via the respiratory tract where particulate burden accumulates depending on sites of particle...
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Physiologically Based Biopharmaceutics Modeling for Gefapixant IR Formulation Development and Defining the Bioequivalence Dissolution Safe Space
Gefapixant is a weakly basic drug which has been formulated as an immediate release tablet for oral administration. A physiologically based...
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Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation Inhibition
ObjectivesPolymeric excipients play an important role in a cocrystal formulation to act as precipitation inhibitors to maximize the potential....
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Effect of Food Viscosity on Drug Dissolution
PurposeThe purpose of the present study was to investigate the effect of food viscosity on the dissolution rate of a drug. There are two types of...
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New Insight into Acidifier-Induced Enhancement of Dissolution of Weakly Basic Drug, Dipyridamole
ObjectiveMost studies regarding acidifiers focused on their role in improving the dissolution performance of a drug by altering the pH of the...
