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Prospective associations of leucocyte subtypes and obesity with the risk of develo** cutaneous malignant melanoma in the UK Biobank cohort
BackgroundObesity is associated with chronic low-grade inflammation, which is linked to cancer development. Abdominal obesity (a body mass index,...
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Exploring of miR-155-5p, miR-181b-5p, and miR-454-3p Expressions in Circulating Cell-Free RNA: Insights from Peripheral Blood of Uveal Malignant Melanoma Patients
The identification of novel non-invasive biomarkers is imperative for the early diagnosis and monitoring of malignant melanoma. The objective of this...
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A Japanese case of familial malignant melanoma with germline CDK4 variant incidentally diagnosed by cancer genome profiling
Familial malignant melanoma (FMM) is a hereditary tumor that is quite rare in Japan; to date, the germline CDK4 variant has scarcely been reported...
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Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment
BackgroundTumor cell-induced platelet aggregation (TCIPA) is not only a recognized mechanism for paraneoplastic thrombocytosis but also a potential...
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Therapeutic applications of local injection of hsa-miR-634 into canine spontaneous malignant melanoma tumors
Malignant melanoma (MM) is one of the most common tumors in both dogs and humans. As canine MM (CMM) and human MM (HMM) have similar clinical...
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Melanoma risk, tumour stage, and melanoma-specific mortality in individuals with diabetes: a systematic review and meta-analysis
BackgroundCancer has become the leading diabetes-related cause of death in high-income countries, and more knowledge is needed to clarify the impact...
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Immune checkpoint inhibitor (ICI) genes and aging in malignant melanoma patients: a clinicogenomic TCGA study
BackgroundCancer diagnoses and deaths among the elderly (65 +) are expected to increase significantly over the next decade. Immune checkpoint...
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High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types
BackgroundA regional skin cancer prevention program in Eastern Finland revealed a relatively high age-standardized mortality due to malignant...
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IRF4-activated TEX41 promotes the malignant behaviors of melanoma cells by targeting miR-103a-3p/C1QB axis
BackgroundMalignant melanoma is an aggressive skin cancer and a tumor of melanocytic origin. Recent studies have suggested that long non-coding RNAs...
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Immunotherapy for Cutaneous Melanoma
Melanoma is the most aggressive skin cancer whose incidence is increasing in western countries. Among novel treatments, immunotherapy has shown...
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Dormancy of cutaneous melanoma
Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most...
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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st–3rd, 2022—Naples, Italy)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune...
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ERBB3 binding protein 1 promotes the progression of malignant melanoma through activation of the Wnt/ β-catenin signaling pathway
BackgroundMalignant melanoma (MM) is highly metastatic and has the highest mortality rate in patients with skin cancer. The ERBB3 binding protein 1...
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Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
BackgroundThe mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has...
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The role of mitochondria in the resistance of melanoma to PD-1 inhibitors
Malignant melanoma is one of the most common tumours and has the highest mortality rate of all types of skin cancers worldwide. Traditional and novel...
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Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank
BackgroundPhysical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation...
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The Immunogenetics of Melanoma
MelanomaMelanoma is a relatively common and deadly type of skin cancer that originates from melanocytes. Cutaneous malignant melanoma results from...
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Correlation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis
BackgroundThe role of hemoglobin (HGB) in common malignant tumors remains unclear.
MethodsA retrospective analysis was conducted to identify the...
