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Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination
BackgroundMultiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by activated neuroglial cells, CNS...
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Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions
Neutrophils are the essential guards of the immune system that inactivate different pathogens as well as instruct specific immune responses. Nitric...
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Nitric Oxide
Nitric oxide (NO) is a gaseous molecule with the chemical formula NO. In biological systems, NO is produced from L-arginine by three distinct NO...
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Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Diabetes, alcohol abuse, and combination antiretroviral therapy (cART) use have been reported to cause multi-organ complications via induction of...
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Nitric Oxide and Cardiovascular Health
Nitric oxide (NO) is a diffusible free radical and universal messenger that is produced from L-arginine by three different isoforms of nitric oxide...
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Effect of Nitric Oxide Synthase Inhibitor on the Learning and Spatial Memory in Rats Subjected to Long-Term Perinatal Administration of Caffeine
We studied the effect of inducible nitric oxide synthase inhibitor aminoguanidine on learning and spatial memory in rats exposed to long-term...
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Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea
Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like Foeniculum vulgare and Peumus boldus and is used to treat...
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Nitric Oxide Regulation in Microparticles
Nitric oxide (NO) has been widely shown to have a varied roles physiologically. Nitric oxide presence in microparticle has been gaining importance...
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Nitric Oxide and the Heart Autonomic Nervous System
Nitric oxide (NO) is important in physiological cardiovascular regulation and is involved in the pathophysiology of cardiac disorders. This chapter...
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Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challenges and high relapse rates....
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Influence of a Nitric Oxide Synthase Inhibitor on the Anxiolytic, Stimulating, and Analgesic Effects of Long-Term Perinatal Caffeine Exposure in Rats
We studied the effect of inducible NO synthase (iNOS) inhibitor aminoguanidine on the behavioral effects of chronic perinatal caffeine exposure....
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Sex Differences in Stress and Stress Related Neuropsychiatric Disorders: Focus on Nitric Oxide
Sex differences in neuropsychiatric disorders are well reported although the mechanisms remain poorly understood. The prevalence of major depressive...
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Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy
BackgroundAcute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high...
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Nitric Oxide in Parkinson’s Disease: Insights into Research and Therapeutics
Parkinson’s disease (PD) is characterized by the symptoms of motor and cognitive deficits. There are several approaches available for the treatment...
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Involvement of Nitric Oxide in Insulin Secretion to Carbohydrate Metabolism
Since the discovery of nitric oxide (NO) as an important mediator of vasoregulation, the molecule has been found to be involved in several...
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The Negative Impact of Cancer Cell Nitric Oxide on Photodynamic Therapy
Numerous studies have shown that low-flux nitric oxide (NO) in tumors produced mainly by inducible nitric oxide synthase (iNOS/NOS2) can signal for...
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Evidence of Nitric Oxide Impairment During Hypertensive Pregnancies
Hypertensive disorders of pregnancy complicate up to 10% of pregnancies worldwide, and they can be classified into (1) gestational hypertension, (2)...
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Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway
Cholestasis describes bile secretion or flow impairment, which is clinically manifested with fatigue, pruritus, and jaundice. Neutrophils play a...
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Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
BackgroundPruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...
