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Point of Care Molecular Diagnostics in Cancer
Among the major challenges facing the clinical applications of point of care (PoC) devices is to enable rapid, accurate, convenient, and...
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Point of Care Molecular Diagnostics in Cancer
Among the major challenges facing the clinical applications of point of care (PoC) devices is to enable rapid, accurate, convenient, and...
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Is ovarian cancer surgery stuck in the dark ages?: a commentary piece reviewing surgical technologies
Ovarian cancer surgery endeavours to remove all visible tumour deposits, and surgical technologies could potentially facilitate this aim. However,...
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Rethinking our approach to cancer metabolism to deliver patient benefit
Altered cellular metabolism is a major mechanism by which tumours support nutrient consumption associated with increased cellular proliferation....
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The surgical intelligent knife distinguishes normal, borderline and malignant gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS)
BackgroundSurvival from ovarian cancer (OC) is improved with surgery, but surgery can be complex and tumour identification, especially for borderline...
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Exploring Cancer Metabolism: Applications of Metabolomics and Metabolic Phenoty** in Cancer Research and Diagnostics
Altered metabolism is one of the key hallmarks of cancer. The development of sensitive, reproducible and robust bioanalytical tools such as Nuclear...
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Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery...
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Mass spectrometry imaging in gynecological cancers: the best is yet to come
Mass spectrometry imaging (MSI) enables obtaining multidimensional results simultaneously in a single run, including regiospecificity and m/z values...
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Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery
BackgroundRe-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20–25%), is cost-inefficient,...
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Approaching Pancreatic Cancer Phenotypes via Metabolomics
Metabolomics, one of the latest omics’ technologies, focuses on the global, quantitative, and simultaneous measurement of endogenous metabolites in a...
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Tissue Identification in a Porcine Model by Differential Ion Mobility Spectrometry Analysis of Surgical Smoke
Electrosurgery is widely used in various surgical operations. When tissue is cut with high-frequency current, the cell contents at the incision area...
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New technologies – new insights into the pathogenesis of hepatic encephalopathy
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a...
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Emerging applications of metabolomics in drug discovery and precision medicine
Metabolomics is an emerging 'omics' science involving the comprehensive characterization of metabolites and metabolism in biological systems. Recent...
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Approaching Pancreatic Cancer Phenotypes via Metabolomics
Metabolomics, one of the latest omics’ technologies, focuses on the global, quantitative, and simultaneous measurement of endogenous metabolites in a...
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Drug Repurposing to Circumvent Chemotherapy Resistance in Brain Tumours
The incidence of primary brain tumours in the UK is steadily rising; prognosis for this devastating disease is dismal and not significantly...