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Galaninergic and hypercapnia-activated neuronal projections to the ventral respiratory column
In mammals, the ventral respiratory column (VRC) plays a pivotal role in integrating neurochemically diverse inputs from brainstem and forebrain...
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Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia
Isolated exposure to intermittent hypoxia and permissive hypercapnia activates signaling mechanisms that induce ultrastructural changes in...
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Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults
Excessive arterial pressure elevation induced by resistance exercise (RE) attenuates peripheral vasodilatory function, but its effect on...
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Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans
Muscle metaboreflex activation during hypercapnia leads to enhanced pressive effects that are poorly understood while autonomic responses including...
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High-but not moderate-intensity exercise acutely attenuates hypercapnia-induced vasodilation of the internal carotid artery in young men
PurposeExercise-induced increases in shear rate (SR) across different exercise intensities may differentially affect hypercapnia-induced vasodilation...
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Hypercapnia Modulates the Activity of Adenosine A1 Receptors and mitoK+ATP-Channels in Rat Brain When Exposed to Intermittent Hypoxia
AbstractThe mechanisms and signaling pathways of the neuroprotective effects of hypercapnia and its combination with hypoxia are not studied...
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Hypercapnia and Hypoxia Stimulate Proliferation of Astrocytes and Neurons In Vitro
We compared proliferative activity and hypoxic tolerance in a co-culture of neurons and astrocytes in vitro after preliminary exposure to normobaric...
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Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats
Active expiration represents an important mechanism to improve ventilation in conditions of augmented ventilatory demand, such as hypercapnia. While...
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The effect of hypercapnia on regional cerebral blood flow regulation during progressive lower-body negative pressure
PurposePrevious work indicates that dynamic cerebral blood flow (CBF) regulation is impaired during hypercapnia; however, less is known about the...
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African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia
Naked mole-rats are extremely tolerant to low concentrations of oxygen (hypoxia) and high concentrations of carbon dioxide (hypercapnia), which is...
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The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults
We compared the differences in cerebrovascular and cognitive function between 13 aerobic exercise trained, older adults and 13 age-, height- and...
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Hypercapnia Exacerbates the Blood–Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats
Hypercapnia in combination with hypoxemia is usually present in severe respiratory disease in the intensive care unit (ICU) and can lead to more...
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CO2 exposure enhances Fos expression in hypothalamic neurons in rats during the light and dark phases of the diurnal cycle
Orexinergic (OX) neurons in the lateral hypothalamus (LH), perifornical area (PFA) and dorsomedial hypothalamus (DMH) play a role in the hypercapnic...
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An assessment of hypercapnia-induced elevations in regional cerebral perfusion during combined orthostatic and heat stresses
We investigated that the effects of hypercapnia-induced elevations in cerebral perfusion during a heat stress on global cerebrovascular responses to...
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Of Mice and Men and Plethysmography Systems: Does LKB1 Determine the Set Point of Carotid Body Chemosensitivity and the Hypoxic Ventilatory Response?
Our recent studies suggest that the level of liver kinase B1 (LKB1) expression in some way determines carotid body afferent discharge during hypoxia...
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Noninvasive Ventilation in Obesity Hypoventilation Syndrome: What Practitioners Need to Know?
Obesity Hypoventilation Syndrome (OHS) is one of the complications of obesity. When compared to simple obesity and eucapnic obstructive sleep apnea,...
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Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s disease
BackgroundHuntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting...
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Effects of Voluntary Changes in Minute Ventilation on Microvascular Skin Blood Flow
PurposePerforming yoga exercises in addition to basic training helps athletes to improve their results. At the same time, yoga exercises, including...
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Chronic Metformin Administration Does Not Alter Carotid Sinus Nerve Activity in Control Rats
Metformin is a glucose-lowering, insulin-sensitizing drug that is commonly used in the treatment of type 2 diabetes (T2D). In the last decade, the...