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Gelatin In Situ Zymography to Study Gelatinase Activity in Colon Cancer Cells Treated with Platelet Microparticles (PMPs)
The platelet-derived microparticles (PMPs) have been connected with tumor progression and metastatic dissemination. PMPs infiltrate solid tumors and...
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An Experimental Design Approach for Development of Crocin-Loaded Microparticles Embedded in Gelatin/Oxidized Alginate-Based Hydrogel
PurposeThe objective of this study was to prepare gelatin/oxidized alginate (OAlg) hydrogel incorporating chitosan (CS)/alginate (Alg) microparticles...
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Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration
Degenerative disc disease (DDD) is the leading cause of excruciating lower back pain and disability in adults worldwide. Among the current treatments...
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Novel therapeutic approach for the treatment of cystic fibrosis based on freeze-dried tridrug microparticles to treat cystic fibrosis
BackgroundCystic fibrosis is a severe, autosomal recessive disease that shortens life expectancy. According to studies, approximately 27% of patients...
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Microparticles, Microspheres, and Microemulsions in Respiratory Diseases
The term microparticles refers to particles that boast in the size range of micrometers. These may be described as solid particles or particulate...
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Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
BackgroundCancer stem cells (CSCs) are a subpopulation of cancer cells that are believed to be responsible for tumor initiation, progression,...
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Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing
This work combines natural polymers with nanoemulsions (NEs) to formulate nanocomposites as an innovative wound dressing. Spray-drying has been used...
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Multifunctional Microparticles Incorporating Gold Compound Inhibit Human Lung Cancer Xenograft
PurposeGold porphyrin (AuP) is a complex that has been shown to be potent against various tumors. A biocompatible interpenetrating network (IPN)...
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Pharmacokinetics and hypoglycemic effect of gliclazide loaded in Isabgol husk mucilage microparticles
PurposeAmong the several therapeutic agents available for the management of diabetes mellitus, sulfonylureas such as gliclazide have several...
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Synbiotics in Oral Drug Delivery
Gut microbiota constitutes a variety of microorganism like bacteria, fungi, virus, rickettsiae, etc. Any imbalance in gut microbiota termed as...
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Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging because the aerodynamic properties of nanomaterials are...
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Fibroin-Gelatin Composite Stimulates the Regeneration of a Splinted Full-Thickness Skin Wound in Mice
The effects of composite fibroin-gelatin microparticles (100-250 μ) on the rate of wound healing and regeneration under conditions of contraction...
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Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration
Evidence that otoliths, mineral-rich limestone concrescences present in the inner ear of bone fishes, can accelerate bone formation in vivo has been...
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Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation
BackgroundDexamethasone (DEX) is a well-known anti-inflammatory and immunosuppressive drug applied broadly as an osteoinductive agent in bone...
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Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery
BackgroundPulmonary drug delivery is an efficient way to deliver drugs directly to the site of action i.e., lungs or to the blood circulation with...
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Quality Risk Management and Quality by Design for the Development of Diclofenac Sodium Intra-articular Gelatin Microspheres
The aim of the present study was to evaluate the development of an intra-articular nonsteroidal anti-inflammatory drug gelatin microsphere...
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Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum
BackgroundCurrently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on...
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Promoted Antitumor Activity of Myricetin against Lung Carcinoma Via Nanoencapsulated Phospholipid Complex in Respirable Microparticles
PurposeMyricetin (MYR) flavonoid is well-recognized for its antioxidant, anti-inflammatory and anti-tumor potential. Introducing nanomedicine was the...
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Sustained Release Ziprasidone Microparticles Prepared by Spray Drying with Soluplus® and Ethyl Cellulose to Eliminate Food Effect and Enhance Bioavailability
The purpose of this study was to develop and evaluate a new formulation of ziprasidone (ZIP) for improved fasted state absorption and sustained drug...
