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Characteristics of Inflammatory and Normal Endothelial Exosomes on Endothelial Function and the Development of Hypertension
Endothelial dysfunction is associated with the development of hypertension. We hypothesize that inflammatory and normal endothelial exosomes play...
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HDL and Endothelial Function
Plasmid high-density lipoprotein (HDL) is a critical biomarker in predicting cardiovascular diseases. Endothelial cells are physically located in the...
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Endothelial Cells Promote Pseudo-islet Function Through BTC-EGFR-JAK/STAT Signaling Pathways
Interactions between cells are of fundamental importance in affecting cell function. In vivo, endothelial cells and islet cells are close to each...
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Evaluation of Glycolysis and Mitochondrial Function in Endothelial Cells Using the Seahorse Analyzer
Endothelial bioenergetics have emerged as a key regulator of endothelial barrier function. Glycolytic parameters have been linked to barrier...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers
Endothelial dysfunction occurs early in the development of atherosclerosis and predicts the development of cardiovascular events in T2DM. The...
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Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation
The blood-brain barrier consists of tightly connected endothelial cells protecting the brain’s microenvironment from the periphery. These endothelial...
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Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives
Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the existing ones, playing critical roles in physiological and...
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Impairment of endothelial function in Parkinson’s disease
ObjectiveThere are conflicting data regarding the relationship between Parkinson’s disease (PD) and the atherosclerotic process. This study aimed to...
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Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their success is limited owing to insufficient efficacy and...
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Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products
Cigarette smoking is the most important avoidable cardiovascular risk factor. It causes endothelial dysfunction and atherosclerosis and increases the...
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Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
BackgroundFructose is a very common sugar found in natural foods, while current studies demonstrate that high fructose intake is significantly...
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Estrone-mediated lowering of ROS and NOX4 improves endothelial function in ovariectomized wistar rats
Estrone (E1) constitutes the primary component in oral conjugated equine estrogens (CEEs) and serves as the principal estrogen precursor in the...
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Effect of Carotid Body Denervation on Systemic Endothelial Function in a Diabetic Animal Model
Endothelial dysfunction is an essential intermediary for development of cardiovascular diseases associated with diabetes and hypertension (HT). The...
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Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function
Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Non-circulatory Methods of Measurement
The endothelium is a vital organ important for regulating vascular homeostasis. Endothelial dysfunction in type 2 diabetes has been linked to the...
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Effect of Apolipoprotein E isoforms on the Abundance and Function of P-glycoprotein in Human Brain Microvascular Endothelial Cells
BackgroundIndividuals with Alzheimer’s disease (AD) often require many medications; however, these medications are dosed using regimens recommended...
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Effect of low-molecular-weight heparin calcium combined with magnesium sulfate and labetalol on coagulation, vascular endothelial function and pregnancy outcome in early-onset severe preeclampsia
ObjectiveThis paper was aimed at unveiling the effect of low-molecular-weight heparin calcium (LMWH) combined with magnesium sulfate and labetalol on...
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iPSC-Derived Corneal Endothelial Cells
The corneal endothelium is the innermost monolayer of the cornea that maintains corneal transparency and thickness. However, adult human corneal...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers
Endothelial dysfunction occurs early in the development of atherosclerosis and predicts the development of cardiovascular events in T2DM. The...
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Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease
Vascular endothelial inflammation and endothelial dysfunction are the main causes of endothelial injury in Kawasaki disease (KD). Human umbilical...
